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Presenilin 1 transgene addition to amyloid precursor protein overexpressing transgenic rats increases amyloid beta 42 levels and results in loss of memory retention

BACKGROUND: We previously reported the production of transgenic rats (APP21 line) that over-express human amyloid precursor protein (APP) containing Swedish and Indiana mutations. In order to generate a better model for Alzheimer’s disease (AD), the APP21 rat line was used to generate double transge...

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Detalles Bibliográficos
Autores principales:	Agca, Cansu, Klakotskaia, Diana, Schachtman, Todd R., Chan, Anthony W., Lah, James J., Agca, Yuksel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936262/ https://www.ncbi.nlm.nih.gov/pubmed/27388605 http://dx.doi.org/10.1186/s12868-016-0281-8

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