Stilbenoids remodel the DNA methylation patterns in breast cancer cells and inhibit oncogenic NOTCH signaling through epigenetic regulation of MAML2 transcriptional activity

DNA hypomethylation was previously implicated in cancer progression and metastasis. The purpose of this study was to examine whether stilbenoids, resveratrol and pterostilbene thought to exert anticancer effects, target genes with oncogenic function for de novo methylation and silencing, leading to...

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Detalles Bibliográficos
Autores principales: Lubecka, Katarzyna, Kurzava, Lucinda, Flower, Kirsty, Buvala, Hannah, Zhang, Hao, Teegarden, Dorothy, Camarillo, Ignacio, Suderman, Matthew, Kuang, Shihuan, Andrisani, Ourania, Flanagan, James M., Stefanska, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Manuscript
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936385/
https://www.ncbi.nlm.nih.gov/pubmed/27207652
http://dx.doi.org/10.1093/carcin/bgw048

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