Cargando…

Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure

This article reviews studies of progenitor mobilization with gamma-tocotrienol (GT3), a tocol under advanced development as a radiation countermeasure for acute radiation syndrome (ARS). GT3 protects mice against high doses of ionizing radiation and induces high levels of granulocyte colony-stimulat...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Vijay K., Fatanmi, Oluseyi O., Verma, Amit, Newman, Victoria L., Wise, Stephen Y., Romaine, Patricia L.P., Berg, Allison N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936433/
https://www.ncbi.nlm.nih.gov/pubmed/27356050
http://dx.doi.org/10.1097/HP.0000000000000458
_version_ 1782441559189356544
author Singh, Vijay K.
Fatanmi, Oluseyi O.
Verma, Amit
Newman, Victoria L.
Wise, Stephen Y.
Romaine, Patricia L.P.
Berg, Allison N.
author_facet Singh, Vijay K.
Fatanmi, Oluseyi O.
Verma, Amit
Newman, Victoria L.
Wise, Stephen Y.
Romaine, Patricia L.P.
Berg, Allison N.
author_sort Singh, Vijay K.
collection PubMed
description This article reviews studies of progenitor mobilization with gamma-tocotrienol (GT3), a tocol under advanced development as a radiation countermeasure for acute radiation syndrome (ARS). GT3 protects mice against high doses of ionizing radiation and induces high levels of granulocyte colony-stimulating factor (G-CSF). GT3‐induced G-CSF in conjunction with AMD3100 (a chemokine receptor antagonist clinically used to improve the yield of mobilized progenitors) mobilizes progenitors; these mobilized progenitors mitigate injury when infused to mice exposed to acute, high-dose ionizing radiation. The administration of a G-CSF antibody to GT3‐injected donor mice abrogated the radiomitigative efficacy of blood or peripheral blood mononuclear cells (PBMC) in irradiated recipient mice. The efficacy of GT3‐injected donor mice blood or PBMC was comparable to a recently published article involving blood or mononuclear cells obtained from mice injected with G-CSF. The injected progenitors were found to localize in various tissues of irradiated hosts. The authors demonstrate the efficacy of a bridging therapy in a preclinical animal model that allows the lymphohematopoietic system of severely immunocompromised mice to recover. This suggests that GT3 is a highly effective agent for radioprotection and mobilizing progenitors with significant therapeutic potential. Therefore, GT3 may be considered for further translational development and ultimately for use in humans.
format Online
Article
Text
id pubmed-4936433
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-49364332016-07-26 Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure Singh, Vijay K. Fatanmi, Oluseyi O. Verma, Amit Newman, Victoria L. Wise, Stephen Y. Romaine, Patricia L.P. Berg, Allison N. Health Phys Papers This article reviews studies of progenitor mobilization with gamma-tocotrienol (GT3), a tocol under advanced development as a radiation countermeasure for acute radiation syndrome (ARS). GT3 protects mice against high doses of ionizing radiation and induces high levels of granulocyte colony-stimulating factor (G-CSF). GT3‐induced G-CSF in conjunction with AMD3100 (a chemokine receptor antagonist clinically used to improve the yield of mobilized progenitors) mobilizes progenitors; these mobilized progenitors mitigate injury when infused to mice exposed to acute, high-dose ionizing radiation. The administration of a G-CSF antibody to GT3‐injected donor mice abrogated the radiomitigative efficacy of blood or peripheral blood mononuclear cells (PBMC) in irradiated recipient mice. The efficacy of GT3‐injected donor mice blood or PBMC was comparable to a recently published article involving blood or mononuclear cells obtained from mice injected with G-CSF. The injected progenitors were found to localize in various tissues of irradiated hosts. The authors demonstrate the efficacy of a bridging therapy in a preclinical animal model that allows the lymphohematopoietic system of severely immunocompromised mice to recover. This suggests that GT3 is a highly effective agent for radioprotection and mobilizing progenitors with significant therapeutic potential. Therefore, GT3 may be considered for further translational development and ultimately for use in humans. Lippincott Williams & Wilkins 2016-08 2016-07-01 /pmc/articles/PMC4936433/ /pubmed/27356050 http://dx.doi.org/10.1097/HP.0000000000000458 Text en Copyright © 2016 Health Physics Society This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Papers
Singh, Vijay K.
Fatanmi, Oluseyi O.
Verma, Amit
Newman, Victoria L.
Wise, Stephen Y.
Romaine, Patricia L.P.
Berg, Allison N.
Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure
title Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure
title_full Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure
title_fullStr Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure
title_full_unstemmed Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure
title_short Progenitor Cell Mobilization by Gamma-tocotrienol: A Promising Radiation Countermeasure
title_sort progenitor cell mobilization by gamma-tocotrienol: a promising radiation countermeasure
topic Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936433/
https://www.ncbi.nlm.nih.gov/pubmed/27356050
http://dx.doi.org/10.1097/HP.0000000000000458
work_keys_str_mv AT singhvijayk progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure
AT fatanmioluseyio progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure
AT vermaamit progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure
AT newmanvictorial progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure
AT wisestepheny progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure
AT romainepatricialp progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure
AT bergallisonn progenitorcellmobilizationbygammatocotrienolapromisingradiationcountermeasure