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Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice

The dysfunction of endothelial progenitor cells (EPCs) was found to be associated with vascular complications in diabetes mellitus (DM) patients. Previous studies found that regular exercise could improve the function of EPCs in DM patients, but the underling mechanism was unclear. Irisin, a newly i...

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Autores principales: Zhu, Guangxu, Wang, Jinxiang, Song, Mingbao, Zhou, Fang, Fu, Dagan, Ruan, Guangping, Zhu, Xiangqing, Bai, Yinyin, Huang, Lan, Pang, Rongqing, Kang, Huali, Pan, Xinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Cardiovascular Pharmacology 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936438/
https://www.ncbi.nlm.nih.gov/pubmed/27002278
http://dx.doi.org/10.1097/FJC.0000000000000386
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author Zhu, Guangxu
Wang, Jinxiang
Song, Mingbao
Zhou, Fang
Fu, Dagan
Ruan, Guangping
Zhu, Xiangqing
Bai, Yinyin
Huang, Lan
Pang, Rongqing
Kang, Huali
Pan, Xinghua
author_facet Zhu, Guangxu
Wang, Jinxiang
Song, Mingbao
Zhou, Fang
Fu, Dagan
Ruan, Guangping
Zhu, Xiangqing
Bai, Yinyin
Huang, Lan
Pang, Rongqing
Kang, Huali
Pan, Xinghua
author_sort Zhu, Guangxu
collection PubMed
description The dysfunction of endothelial progenitor cells (EPCs) was found to be associated with vascular complications in diabetes mellitus (DM) patients. Previous studies found that regular exercise could improve the function of EPCs in DM patients, but the underling mechanism was unclear. Irisin, a newly identified myokine, was induced by exercise and has been demonstrated to mediate some of the positive effects of exercise. In this study, we hypothesize that irisin may have direct effects on EPC function in DM mice. These data showed for the first time that irisin increased the number of EPCs in peripheral blood of DM mice and improved the function of EPCs derived from DM mice bone marrow. The mechanism for the effect of irisin is related to the PI3K/Akt/eNOS pathway. Furthermore, irisin was demonstrated to improve endothelial repair in DM mice that received EPC transplants after carotid artery injury. The results of this study indicate a novel effect of irisin in regulating the number and function of EPCs via the PI3K/Akt/eNOS pathway, suggesting a potential for the administration of exogenous irisin as a succedaneum to improve EPC function in diabetic patients who fail to achieve such improvements through regular exercise.
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spelling pubmed-49364382016-07-26 Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice Zhu, Guangxu Wang, Jinxiang Song, Mingbao Zhou, Fang Fu, Dagan Ruan, Guangping Zhu, Xiangqing Bai, Yinyin Huang, Lan Pang, Rongqing Kang, Huali Pan, Xinghua J Cardiovasc Pharmacol Original Article The dysfunction of endothelial progenitor cells (EPCs) was found to be associated with vascular complications in diabetes mellitus (DM) patients. Previous studies found that regular exercise could improve the function of EPCs in DM patients, but the underling mechanism was unclear. Irisin, a newly identified myokine, was induced by exercise and has been demonstrated to mediate some of the positive effects of exercise. In this study, we hypothesize that irisin may have direct effects on EPC function in DM mice. These data showed for the first time that irisin increased the number of EPCs in peripheral blood of DM mice and improved the function of EPCs derived from DM mice bone marrow. The mechanism for the effect of irisin is related to the PI3K/Akt/eNOS pathway. Furthermore, irisin was demonstrated to improve endothelial repair in DM mice that received EPC transplants after carotid artery injury. The results of this study indicate a novel effect of irisin in regulating the number and function of EPCs via the PI3K/Akt/eNOS pathway, suggesting a potential for the administration of exogenous irisin as a succedaneum to improve EPC function in diabetic patients who fail to achieve such improvements through regular exercise. Journal of Cardiovascular Pharmacology 2016-07 2016-03-22 /pmc/articles/PMC4936438/ /pubmed/27002278 http://dx.doi.org/10.1097/FJC.0000000000000386 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND) (http://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits downloading and sharing the work provided it is properly cited. The work cannot be changed in any way or used commercially.
spellingShingle Original Article
Zhu, Guangxu
Wang, Jinxiang
Song, Mingbao
Zhou, Fang
Fu, Dagan
Ruan, Guangping
Zhu, Xiangqing
Bai, Yinyin
Huang, Lan
Pang, Rongqing
Kang, Huali
Pan, Xinghua
Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
title Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
title_full Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
title_fullStr Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
title_full_unstemmed Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
title_short Irisin Increased the Number and Improved the Function of Endothelial Progenitor Cells in Diabetes Mellitus Mice
title_sort irisin increased the number and improved the function of endothelial progenitor cells in diabetes mellitus mice
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936438/
https://www.ncbi.nlm.nih.gov/pubmed/27002278
http://dx.doi.org/10.1097/FJC.0000000000000386
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