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Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome

Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) is an emerging therapy for severe cases of TS. We studied two patients with TS implanted with bilateral Medtronic Activa PC + S DBS devices, capable of chronic recording...

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Autores principales: Shute, Jonathan B., Okun, Michael S., Opri, Enrico, Molina, Rene, Rossi, P. Justin, Martinez-Ramirez, Daniel, Foote, Kelly D., Gunduz, Aysegul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936504/
https://www.ncbi.nlm.nih.gov/pubmed/27419067
http://dx.doi.org/10.1016/j.nicl.2016.06.015
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author Shute, Jonathan B.
Okun, Michael S.
Opri, Enrico
Molina, Rene
Rossi, P. Justin
Martinez-Ramirez, Daniel
Foote, Kelly D.
Gunduz, Aysegul
author_facet Shute, Jonathan B.
Okun, Michael S.
Opri, Enrico
Molina, Rene
Rossi, P. Justin
Martinez-Ramirez, Daniel
Foote, Kelly D.
Gunduz, Aysegul
author_sort Shute, Jonathan B.
collection PubMed
description Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) is an emerging therapy for severe cases of TS. We studied two patients with TS implanted with bilateral Medtronic Activa PC + S DBS devices, capable of chronic recordings, with depth leads in the thalamic centromedian–parafascicular complex (CM-PF) and subdural strips over the precentral gyrus. Low-frequency (1–10 Hz) CM-PF activity was observed during tics, as well as modulations in beta rhythms over the motor cortex. Tics were divided into three categories: long complex, complex, and simple. Long complex tics, tics involving multiple body regions and lasting longer than 5 s, were concurrent with a highly detectable thalamocortical signature (average recall [sensitivity] 88.6%, average precision 96.3%). Complex tics were detected with an average recall of 63.9% and precision of 36.6% and simple tics an average recall of 39.3% and precision of 37.9%. The detections were determined using data from both patients.
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spelling pubmed-49365042016-07-14 Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome Shute, Jonathan B. Okun, Michael S. Opri, Enrico Molina, Rene Rossi, P. Justin Martinez-Ramirez, Daniel Foote, Kelly D. Gunduz, Aysegul Neuroimage Clin Regular Article Tourette syndrome (TS) is a neuropsychiatric disorder characterized by multiple motor and vocal tics. Deep brain stimulation (DBS) is an emerging therapy for severe cases of TS. We studied two patients with TS implanted with bilateral Medtronic Activa PC + S DBS devices, capable of chronic recordings, with depth leads in the thalamic centromedian–parafascicular complex (CM-PF) and subdural strips over the precentral gyrus. Low-frequency (1–10 Hz) CM-PF activity was observed during tics, as well as modulations in beta rhythms over the motor cortex. Tics were divided into three categories: long complex, complex, and simple. Long complex tics, tics involving multiple body regions and lasting longer than 5 s, were concurrent with a highly detectable thalamocortical signature (average recall [sensitivity] 88.6%, average precision 96.3%). Complex tics were detected with an average recall of 63.9% and precision of 36.6% and simple tics an average recall of 39.3% and precision of 37.9%. The detections were determined using data from both patients. Elsevier 2016-06-25 /pmc/articles/PMC4936504/ /pubmed/27419067 http://dx.doi.org/10.1016/j.nicl.2016.06.015 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Shute, Jonathan B.
Okun, Michael S.
Opri, Enrico
Molina, Rene
Rossi, P. Justin
Martinez-Ramirez, Daniel
Foote, Kelly D.
Gunduz, Aysegul
Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
title Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
title_full Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
title_fullStr Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
title_full_unstemmed Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
title_short Thalamocortical network activity enables chronic tic detection in humans with Tourette syndrome
title_sort thalamocortical network activity enables chronic tic detection in humans with tourette syndrome
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936504/
https://www.ncbi.nlm.nih.gov/pubmed/27419067
http://dx.doi.org/10.1016/j.nicl.2016.06.015
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