Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction

Genome-wide association studies have revealed an association between coronary heart disease (CHD) and genetic variation on chromosome 13q34, with the lead single nucleotide polymorphism rs4773144 residing in the COL4A2 gene in this genomic region. We investigated the functional effects of this genet...

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Detalles Bibliográficos
Autores principales: Yang, Wei, Ng, Fu Liang, Chan, Kenneth, Pu, Xiangyuan, Poston, Robin N., Ren, Meixia, An, Weiwei, Zhang, Ruoxin, Wu, Jingchun, Yan, Shunying, Situ, Haiteng, He, Xinjie, Chen, Yequn, Tan, Xuerui, Xiao, Qingzhong, Tucker, Arthur T., Caulfield, Mark J., Ye, Shu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936713/
https://www.ncbi.nlm.nih.gov/pubmed/27389912
http://dx.doi.org/10.1371/journal.pgen.1006127

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936713/
https://www.ncbi.nlm.nih.gov/pubmed/27389912
http://dx.doi.org/10.1371/journal.pgen.1006127

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