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Activation of the miR-34a/SIRT1/p53 Signaling Pathway Contributes to the Progress of Liver Fibrosis via Inducing Apoptosis in Hepatocytes but Not in HSCs

Liver fibrosis results from a sustained wound healing response to chronic liver injury, and the activation of nonparenchymal hepatic stellate cells (HSCs) is the pivotal process. MicroRNA-34a (miR-34a) is the direct target gene of p53 and activates p53 through sirtuin 1 (SIRT1) simultaneously. The m...

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Detalles Bibliográficos
Autores principales: Tian, Xiao-Feng, Ji, Fu-Jian, Zang, Hong-Liang, Cao, Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936740/
https://www.ncbi.nlm.nih.gov/pubmed/27387128
http://dx.doi.org/10.1371/journal.pone.0158657

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