Human Cytomegalovirus Immediate-Early 1 Protein Rewires Upstream STAT3 to Downstream STAT1 Signaling Switching an IL6-Type to an IFNγ-Like Response

The human cytomegalovirus (hCMV) major immediate-early 1 protein (IE1) is best known for activating transcription to facilitate viral replication. Here we present transcriptome data indicating that IE1 is as significant a repressor as it is an activator of host gene expression. Human cells induced t...

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Detalles Bibliográficos
Autores principales: Harwardt, Thomas, Lukas, Simone, Zenger, Marion, Reitberger, Tobias, Danzer, Daniela, Übner, Theresa, Munday, Diane C., Nevels, Michael, Paulus, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936752/
https://www.ncbi.nlm.nih.gov/pubmed/27387064
http://dx.doi.org/10.1371/journal.ppat.1005748

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936752/
https://www.ncbi.nlm.nih.gov/pubmed/27387064
http://dx.doi.org/10.1371/journal.ppat.1005748

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