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Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers

Lactobacillus plantarum HOKKAIDO (HOKKAIDO strain) was isolated from well-pickled vegetables in Hokkaido, Japan. We report a randomized, double-blind, placebo-controlled study evaluating the effects of L. plantarum HOKKAIDO on immune function and stress markers in 171 adult subjects. Subjects were d...

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Autores principales: Nishimura, Mie, Ohkawara, Tatsuya, Tetsuka, Kyohei, Kawasaki, Yo, Nakagawa, Ryoji, Satoh, Hiroki, Sato, Yuji, Nishihira, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936756/
https://www.ncbi.nlm.nih.gov/pubmed/27419093
http://dx.doi.org/10.1016/j.jtcme.2015.07.003
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author Nishimura, Mie
Ohkawara, Tatsuya
Tetsuka, Kyohei
Kawasaki, Yo
Nakagawa, Ryoji
Satoh, Hiroki
Sato, Yuji
Nishihira, Jun
author_facet Nishimura, Mie
Ohkawara, Tatsuya
Tetsuka, Kyohei
Kawasaki, Yo
Nakagawa, Ryoji
Satoh, Hiroki
Sato, Yuji
Nishihira, Jun
author_sort Nishimura, Mie
collection PubMed
description Lactobacillus plantarum HOKKAIDO (HOKKAIDO strain) was isolated from well-pickled vegetables in Hokkaido, Japan. We report a randomized, double-blind, placebo-controlled study evaluating the effects of L. plantarum HOKKAIDO on immune function and stress markers in 171 adult subjects. Subjects were divided into three groups: the L. plantarum HOKKAIDO yogurt group, the placebo-1 group who ingested yogurt without the HOKKAIDO strain, and the placebo-2 group who ingested a yogurt-like dessert without the HOKKAIDO strain. Hematological tests and body composition measurements were performed before and after 4 and 8 weeks of blinded ingestion. Although no significant differences in natural killer cell activity were observed, it was found that neutrophil ratio significantly decreased and lymphocytes tended to increase in the HOKKAIDO strain yogurt group compared with the yogurt-like dessert group. In addition, the neutrophil-to-lymphocyte ratio, a stress marker, tended to improve in the HOKKAIDO strain yogurt group compared with the yogurt-like dessert group. These results suggest that the ingestion of HOKKAIDO strain yogurt tends to improve immune activity and decrease stress markers.
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spelling pubmed-49367562016-07-14 Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers Nishimura, Mie Ohkawara, Tatsuya Tetsuka, Kyohei Kawasaki, Yo Nakagawa, Ryoji Satoh, Hiroki Sato, Yuji Nishihira, Jun J Tradit Complement Med Original Article Lactobacillus plantarum HOKKAIDO (HOKKAIDO strain) was isolated from well-pickled vegetables in Hokkaido, Japan. We report a randomized, double-blind, placebo-controlled study evaluating the effects of L. plantarum HOKKAIDO on immune function and stress markers in 171 adult subjects. Subjects were divided into three groups: the L. plantarum HOKKAIDO yogurt group, the placebo-1 group who ingested yogurt without the HOKKAIDO strain, and the placebo-2 group who ingested a yogurt-like dessert without the HOKKAIDO strain. Hematological tests and body composition measurements were performed before and after 4 and 8 weeks of blinded ingestion. Although no significant differences in natural killer cell activity were observed, it was found that neutrophil ratio significantly decreased and lymphocytes tended to increase in the HOKKAIDO strain yogurt group compared with the yogurt-like dessert group. In addition, the neutrophil-to-lymphocyte ratio, a stress marker, tended to improve in the HOKKAIDO strain yogurt group compared with the yogurt-like dessert group. These results suggest that the ingestion of HOKKAIDO strain yogurt tends to improve immune activity and decrease stress markers. Elsevier 2015-08-21 /pmc/articles/PMC4936756/ /pubmed/27419093 http://dx.doi.org/10.1016/j.jtcme.2015.07.003 Text en Copyright © 2016, Center for Food and Biomolecules, National Taiwan University. Production and hosting by Elsevier Taiwan LLC. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Article
Nishimura, Mie
Ohkawara, Tatsuya
Tetsuka, Kyohei
Kawasaki, Yo
Nakagawa, Ryoji
Satoh, Hiroki
Sato, Yuji
Nishihira, Jun
Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers
title Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers
title_full Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers
title_fullStr Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers
title_full_unstemmed Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers
title_short Effects of yogurt containing Lactobacillus plantarum HOKKAIDO on immune function and stress markers
title_sort effects of yogurt containing lactobacillus plantarum hokkaido on immune function and stress markers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936756/
https://www.ncbi.nlm.nih.gov/pubmed/27419093
http://dx.doi.org/10.1016/j.jtcme.2015.07.003
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