Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization

Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; 辛夷清肺湯 xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine (日本漢醫 rì běn hàn yī) and traditional Chinese medicine (TCM; 中醫 zhōng yī), has been used for the treatment of chronic sinusitis. The objective of this study was...

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Autores principales: Minami, Masaaki, Konishi, Toru, Jiang, Zhixia, Arai, Tetsuya, Makino, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936765/
https://www.ncbi.nlm.nih.gov/pubmed/27419089
http://dx.doi.org/10.1016/j.jtcme.2015.06.001
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author Minami, Masaaki
Konishi, Toru
Jiang, Zhixia
Arai, Tetsuya
Makino, Toshiaki
author_facet Minami, Masaaki
Konishi, Toru
Jiang, Zhixia
Arai, Tetsuya
Makino, Toshiaki
author_sort Minami, Masaaki
collection PubMed
description Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; 辛夷清肺湯 xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine (日本漢醫 rì běn hàn yī) and traditional Chinese medicine (TCM; 中醫 zhōng yī), has been used for the treatment of chronic sinusitis. The objective of this study was to evaluate the anti-allergic effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization using ovalbumin (OVA) as an antigen. Extract of shin'iseihaito (SSHT) could reduce the eosinophil, serum IgE and interleukin (IL)-4 levels, while increased the interferon (IFN)-γ levels in allergic mouse. Furthermore, allergic-murine serum treated with SSHT could not activate passive cutaneous anaphylaxis (PCA) reaction in murine model. Thus, our study showed that SSHT may possess anti-allergic activity. We suggested that SSHT may contribute to inhibit the exacerbation of allergic reaction induced by nasal sensitization.
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spelling pubmed-49367652016-07-14 Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization Minami, Masaaki Konishi, Toru Jiang, Zhixia Arai, Tetsuya Makino, Toshiaki J Tradit Complement Med Short Communication Shin'iseihaito (Magnolia Flower Lung-Clearing Decoction; 辛夷清肺湯 xīn yí qīng fèi tāng), a formula of traditional Japanese kampo medicine (日本漢醫 rì běn hàn yī) and traditional Chinese medicine (TCM; 中醫 zhōng yī), has been used for the treatment of chronic sinusitis. The objective of this study was to evaluate the anti-allergic effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization using ovalbumin (OVA) as an antigen. Extract of shin'iseihaito (SSHT) could reduce the eosinophil, serum IgE and interleukin (IL)-4 levels, while increased the interferon (IFN)-γ levels in allergic mouse. Furthermore, allergic-murine serum treated with SSHT could not activate passive cutaneous anaphylaxis (PCA) reaction in murine model. Thus, our study showed that SSHT may possess anti-allergic activity. We suggested that SSHT may contribute to inhibit the exacerbation of allergic reaction induced by nasal sensitization. Elsevier 2015-06-21 /pmc/articles/PMC4936765/ /pubmed/27419089 http://dx.doi.org/10.1016/j.jtcme.2015.06.001 Text en © 2015 Center for Food and Biomolecules, National Taiwan University http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Short Communication
Minami, Masaaki
Konishi, Toru
Jiang, Zhixia
Arai, Tetsuya
Makino, Toshiaki
Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization
title Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization
title_full Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization
title_fullStr Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization
title_full_unstemmed Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization
title_short Effect of Shin'iseihaito on murine allergic reaction induced by nasal sensitization
title_sort effect of shin'iseihaito on murine allergic reaction induced by nasal sensitization
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936765/
https://www.ncbi.nlm.nih.gov/pubmed/27419089
http://dx.doi.org/10.1016/j.jtcme.2015.06.001
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