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Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device

PURPOSE: Full-field electroretinograms (ERGs) are used to evaluate retinal function in patients with various types of hereditary and acquired retinal diseases. However, ERG recordings require relatively invasive procedures, including pupillary dilation and the use of contact lens electrodes. Thus, i...

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Autores principales: Nakamura, Natsuko, Fujinami, Kaoru, Mizuno, Yoshinobu, Noda, Toru, Tsunoda, Kazushige
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936817/
https://www.ncbi.nlm.nih.gov/pubmed/27445454
http://dx.doi.org/10.2147/OPTH.S104721
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author Nakamura, Natsuko
Fujinami, Kaoru
Mizuno, Yoshinobu
Noda, Toru
Tsunoda, Kazushige
author_facet Nakamura, Natsuko
Fujinami, Kaoru
Mizuno, Yoshinobu
Noda, Toru
Tsunoda, Kazushige
author_sort Nakamura, Natsuko
collection PubMed
description PURPOSE: Full-field electroretinograms (ERGs) are used to evaluate retinal function in patients with various types of hereditary and acquired retinal diseases. However, ERG recordings require relatively invasive procedures, including pupillary dilation and the use of contact lens electrodes. Thus, it would be helpful to have a simpler and noninvasive screening method. The purpose of this study was to determine whether a new, handheld, portable ERG device, RETeval™, can be used to screen patients for cone dysfunction. PATIENTS AND METHODS: Thirty-five eyes of 35 patients who had reduced cone responses ascertained by a conventional ERG system using contact lens electrodes were studied. The causative diseases included achromatopsia, cone dystrophy, cone-rod dystrophy, retinitis pigmentosa, choroidal dystrophy, autoimmune retinopathy, and Stargardt disease. The flicker ERGs were recorded with the RETeval™ under undilated conditions with skin electrodes (stimulus strength, 3.0 cd·s/m(2); frequency, 28.3 Hz), and the responses were compared to that of 50 healthy eyes. The amplitudes and implicit times of the fundamental component of the flicker ERGs were analyzed in three age groups: Group A, ≤20 years; Group B, 21–40 years; and Group C, ≥41 years. RESULTS: In all of the age groups, the amplitudes of the ERGs were significantly smaller and the implicit times significantly longer in patients with cone dysfunction than in the control eyes. All but one of the patients had flicker amplitudes lower than the mean −2.0 standard deviation of control eyes. CONCLUSION: The RETeval™ has a potential of being used to screen for cone dysfunction. The entire examination takes <5 minutes and does not require pupil dilatation or a contact lens electrode. Although the flicker responses do not provide information on the scotopic functions, the RETeval™ device can be used to determine which patients require additional full-field ERG testing with dilated pupils under both scotopic and photopic conditions.
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spelling pubmed-49368172016-07-21 Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device Nakamura, Natsuko Fujinami, Kaoru Mizuno, Yoshinobu Noda, Toru Tsunoda, Kazushige Clin Ophthalmol Original Research PURPOSE: Full-field electroretinograms (ERGs) are used to evaluate retinal function in patients with various types of hereditary and acquired retinal diseases. However, ERG recordings require relatively invasive procedures, including pupillary dilation and the use of contact lens electrodes. Thus, it would be helpful to have a simpler and noninvasive screening method. The purpose of this study was to determine whether a new, handheld, portable ERG device, RETeval™, can be used to screen patients for cone dysfunction. PATIENTS AND METHODS: Thirty-five eyes of 35 patients who had reduced cone responses ascertained by a conventional ERG system using contact lens electrodes were studied. The causative diseases included achromatopsia, cone dystrophy, cone-rod dystrophy, retinitis pigmentosa, choroidal dystrophy, autoimmune retinopathy, and Stargardt disease. The flicker ERGs were recorded with the RETeval™ under undilated conditions with skin electrodes (stimulus strength, 3.0 cd·s/m(2); frequency, 28.3 Hz), and the responses were compared to that of 50 healthy eyes. The amplitudes and implicit times of the fundamental component of the flicker ERGs were analyzed in three age groups: Group A, ≤20 years; Group B, 21–40 years; and Group C, ≥41 years. RESULTS: In all of the age groups, the amplitudes of the ERGs were significantly smaller and the implicit times significantly longer in patients with cone dysfunction than in the control eyes. All but one of the patients had flicker amplitudes lower than the mean −2.0 standard deviation of control eyes. CONCLUSION: The RETeval™ has a potential of being used to screen for cone dysfunction. The entire examination takes <5 minutes and does not require pupil dilatation or a contact lens electrode. Although the flicker responses do not provide information on the scotopic functions, the RETeval™ device can be used to determine which patients require additional full-field ERG testing with dilated pupils under both scotopic and photopic conditions. Dove Medical Press 2016-06-30 /pmc/articles/PMC4936817/ /pubmed/27445454 http://dx.doi.org/10.2147/OPTH.S104721 Text en © 2016 Nakamura et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Nakamura, Natsuko
Fujinami, Kaoru
Mizuno, Yoshinobu
Noda, Toru
Tsunoda, Kazushige
Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
title Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
title_full Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
title_fullStr Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
title_full_unstemmed Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
title_short Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
title_sort evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936817/
https://www.ncbi.nlm.nih.gov/pubmed/27445454
http://dx.doi.org/10.2147/OPTH.S104721
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