Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman

We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto...

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Autores principales: de Carlo, Talisa E, Adhi, Mehreen, Lu, Chen D, Duker, Jay S, Fujimoto, James G, Waheed, Nadia K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936830/
https://www.ncbi.nlm.nih.gov/pubmed/27398405
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author de Carlo, Talisa E
Adhi, Mehreen
Lu, Chen D
Duker, Jay S
Fujimoto, James G
Waheed, Nadia K
author_facet de Carlo, Talisa E
Adhi, Mehreen
Lu, Chen D
Duker, Jay S
Fujimoto, James G
Waheed, Nadia K
author_sort de Carlo, Talisa E
collection PubMed
description We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch’s membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch’s membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption.
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spelling pubmed-49368302016-07-07 Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman de Carlo, Talisa E Adhi, Mehreen Lu, Chen D Duker, Jay S Fujimoto, James G Waheed, Nadia K Clin Med Rev Case Rep Article We report a case of widespread unilateral drusen in a healthy 31 year old Caucasian woman using multi-modal imaging including ultra-high resolution optical coherence tomography (UHR-OCT). Dilated fundus exam showed multiple drusen-like lesions in the posterior pole without heme or fluid. Fundus auto fluorescence demonstrated hyperautofluorescent at the deposits. Fluorescein angiography revealed mild hyperfluorescence and staining of the lesions. Spectral-domain optical coherence tomography (SD-OCT) OS showed accumulations in the temporal macula at Bruch’s membrane. UHR-OCT provided improved axial resolution compared to the standard 5 μm on the commercial SD-OCT and confirmed the presence of deposits in Bruch’s membrane, consistent with drusen. The retinal layers were draped over the excrescences but did not show any disruption. 2015-10-10 2015 /pmc/articles/PMC4936830/ /pubmed/27398405 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
de Carlo, Talisa E
Adhi, Mehreen
Lu, Chen D
Duker, Jay S
Fujimoto, James G
Waheed, Nadia K
Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman
title Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman
title_full Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman
title_fullStr Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman
title_full_unstemmed Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman
title_short Ultra-High Resolution Optical Coherence Tomography Imaging of Unilateral Drusen in a 31 Year Old Woman
title_sort ultra-high resolution optical coherence tomography imaging of unilateral drusen in a 31 year old woman
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936830/
https://www.ncbi.nlm.nih.gov/pubmed/27398405
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