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Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice

PURPOSE: To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases detected and the resulting implications for clinical routine. METHODS: Records of 896...

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Autores principales: Rusch, Peter, Hoffmann, Oliver, Stickelmann, Anna-L., Böhmer, Stephan, Gätje, Regine, Krüger, Karl G., Niesert, Stefan, Schmidt, Andrea, Kimmig, Rainer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936992/
https://www.ncbi.nlm.nih.gov/pubmed/27398283
http://dx.doi.org/10.1186/s40064-016-2703-6
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author Rusch, Peter
Hoffmann, Oliver
Stickelmann, Anna-L.
Böhmer, Stephan
Gätje, Regine
Krüger, Karl G.
Niesert, Stefan
Schmidt, Andrea
Kimmig, Rainer
author_facet Rusch, Peter
Hoffmann, Oliver
Stickelmann, Anna-L.
Böhmer, Stephan
Gätje, Regine
Krüger, Karl G.
Niesert, Stefan
Schmidt, Andrea
Kimmig, Rainer
author_sort Rusch, Peter
collection PubMed
description PURPOSE: To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases detected and the resulting implications for clinical routine. METHODS: Records of 896 patients with primary breast cancer diagnosed in the Screening Centre and treated in five participating hospitals were analyzed retrospectively. Evaluation included frequency and type of staging procedures and results with respect to distant metastasis and their consequences on clinical management. RESULTS: 894/896 Patients (99.8 %) received staging for distant metastases by bone scintigraphy, chest X-ray and liver sonography and/or CT/MRT diagnostics. Distant metastasis was suggested In 6/894 patients but excluded in 3 by further diagnostics or clinical course. Thus, 3 (0.3 %) were clinically verified to have metastatic disease in bone (n = 2; both pT2) or in bone and lung (n = 1; cT4, cN3). CONCLUSION: Due to the low incidence of verified metastatic disease, the high false positive rate of staging procedures and the unfavorable cost/benefit ratio routine radiological staging should be completely omitted in asymptomatic breast cancer patients diagnosed in a breast cancer screening programme.
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spelling pubmed-49369922016-07-08 Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice Rusch, Peter Hoffmann, Oliver Stickelmann, Anna-L. Böhmer, Stephan Gätje, Regine Krüger, Karl G. Niesert, Stefan Schmidt, Andrea Kimmig, Rainer Springerplus Research PURPOSE: To determine frequency of routine radiological staging of breast cancer patients diagnosed in a German Breast Cancer Screening Center from 2007 to 2014, the incidence and consequences of distant metastases detected and the resulting implications for clinical routine. METHODS: Records of 896 patients with primary breast cancer diagnosed in the Screening Centre and treated in five participating hospitals were analyzed retrospectively. Evaluation included frequency and type of staging procedures and results with respect to distant metastasis and their consequences on clinical management. RESULTS: 894/896 Patients (99.8 %) received staging for distant metastases by bone scintigraphy, chest X-ray and liver sonography and/or CT/MRT diagnostics. Distant metastasis was suggested In 6/894 patients but excluded in 3 by further diagnostics or clinical course. Thus, 3 (0.3 %) were clinically verified to have metastatic disease in bone (n = 2; both pT2) or in bone and lung (n = 1; cT4, cN3). CONCLUSION: Due to the low incidence of verified metastatic disease, the high false positive rate of staging procedures and the unfavorable cost/benefit ratio routine radiological staging should be completely omitted in asymptomatic breast cancer patients diagnosed in a breast cancer screening programme. Springer International Publishing 2016-07-07 /pmc/articles/PMC4936992/ /pubmed/27398283 http://dx.doi.org/10.1186/s40064-016-2703-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Rusch, Peter
Hoffmann, Oliver
Stickelmann, Anna-L.
Böhmer, Stephan
Gätje, Regine
Krüger, Karl G.
Niesert, Stefan
Schmidt, Andrea
Kimmig, Rainer
Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice
title Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice
title_full Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice
title_fullStr Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice
title_full_unstemmed Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice
title_short Distant metastasis detected by routine staging in breast cancer patients participating in the national German screening programme: consequences for clinical practice
title_sort distant metastasis detected by routine staging in breast cancer patients participating in the national german screening programme: consequences for clinical practice
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4936992/
https://www.ncbi.nlm.nih.gov/pubmed/27398283
http://dx.doi.org/10.1186/s40064-016-2703-6
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