Oxidative Stress in Neurodegenerative Diseases

The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neu...

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Autores principales: Niedzielska, Ewa, Smaga, Irena, Gawlik, Maciej, Moniczewski, Andrzej, Stankowicz, Piotr, Pera, Joanna, Filip, Małgorzata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937091/
https://www.ncbi.nlm.nih.gov/pubmed/26198567
http://dx.doi.org/10.1007/s12035-015-9337-5
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author Niedzielska, Ewa
Smaga, Irena
Gawlik, Maciej
Moniczewski, Andrzej
Stankowicz, Piotr
Pera, Joanna
Filip, Małgorzata
author_facet Niedzielska, Ewa
Smaga, Irena
Gawlik, Maciej
Moniczewski, Andrzej
Stankowicz, Piotr
Pera, Joanna
Filip, Małgorzata
author_sort Niedzielska, Ewa
collection PubMed
description The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction.
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spelling pubmed-49370912016-07-19 Oxidative Stress in Neurodegenerative Diseases Niedzielska, Ewa Smaga, Irena Gawlik, Maciej Moniczewski, Andrzej Stankowicz, Piotr Pera, Joanna Filip, Małgorzata Mol Neurobiol Article The pathophysiologies of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and Alzheimer’s disease (AD), are far from being fully explained. Oxidative stress (OS) has been proposed as one factor that plays a potential role in the pathogenesis of neurodegenerative disorders. Clinical and preclinical studies indicate that neurodegenerative diseases are characterized by higher levels of OS biomarkers and by lower levels of antioxidant defense biomarkers in the brain and peripheral tissues. In this article, we review the current knowledge regarding the involvement of OS in neurodegenerative diseases, based on clinical trials and animal studies. In addition, we analyze the effects of the drug-induced modulation of oxidative balance, and we explore pharmacotherapeutic strategies for OS reduction. Springer US 2015-07-22 2016 /pmc/articles/PMC4937091/ /pubmed/26198567 http://dx.doi.org/10.1007/s12035-015-9337-5 Text en © The Author(s) 2015 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Niedzielska, Ewa
Smaga, Irena
Gawlik, Maciej
Moniczewski, Andrzej
Stankowicz, Piotr
Pera, Joanna
Filip, Małgorzata
Oxidative Stress in Neurodegenerative Diseases
title Oxidative Stress in Neurodegenerative Diseases
title_full Oxidative Stress in Neurodegenerative Diseases
title_fullStr Oxidative Stress in Neurodegenerative Diseases
title_full_unstemmed Oxidative Stress in Neurodegenerative Diseases
title_short Oxidative Stress in Neurodegenerative Diseases
title_sort oxidative stress in neurodegenerative diseases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937091/
https://www.ncbi.nlm.nih.gov/pubmed/26198567
http://dx.doi.org/10.1007/s12035-015-9337-5
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