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Single oral dose safety of D-allulose in dogs

Healthy dogs were administered acute oral doses of D-allulose (also called D-psicose) to evaluate its toxicity. Six dogs received oral doses of either a placebo or D-allulose solution (1 and 4 g/kg) on three different study days. One dog experienced vomiting, and five dogs showed transient diarrhea...

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Autores principales: NISHII, Naohito, NOMIZO, Toru, TAKASHIMA, Satoshi, MATSUBARA, Tatsuya, TOKUDA, Masaaki, KITAGAWA, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Veterinary Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937148/
https://www.ncbi.nlm.nih.gov/pubmed/26972334
http://dx.doi.org/10.1292/jvms.15-0676
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author NISHII, Naohito
NOMIZO, Toru
TAKASHIMA, Satoshi
MATSUBARA, Tatsuya
TOKUDA, Masaaki
KITAGAWA, Hitoshi
author_facet NISHII, Naohito
NOMIZO, Toru
TAKASHIMA, Satoshi
MATSUBARA, Tatsuya
TOKUDA, Masaaki
KITAGAWA, Hitoshi
author_sort NISHII, Naohito
collection PubMed
description Healthy dogs were administered acute oral doses of D-allulose (also called D-psicose) to evaluate its toxicity. Six dogs received oral doses of either a placebo or D-allulose solution (1 and 4 g/kg) on three different study days. One dog experienced vomiting, and five dogs showed transient diarrhea when 4 g/kg of D-allulose was administered. All dogs were active and had a good appetite throughout the study period. Blood glucose concentration slightly decreased without a rise in plasma insulin concentration 2 hr after D-allulose administration. Plasma alkaline phosphatase activities showed a mild increase between 12 and 48 hr after D-allulose administration. These data suggested that a single oral dose of D-allulose does not show severe toxicity in dogs.
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spelling pubmed-49371482016-07-11 Single oral dose safety of D-allulose in dogs NISHII, Naohito NOMIZO, Toru TAKASHIMA, Satoshi MATSUBARA, Tatsuya TOKUDA, Masaaki KITAGAWA, Hitoshi J Vet Med Sci Internal Medicine Healthy dogs were administered acute oral doses of D-allulose (also called D-psicose) to evaluate its toxicity. Six dogs received oral doses of either a placebo or D-allulose solution (1 and 4 g/kg) on three different study days. One dog experienced vomiting, and five dogs showed transient diarrhea when 4 g/kg of D-allulose was administered. All dogs were active and had a good appetite throughout the study period. Blood glucose concentration slightly decreased without a rise in plasma insulin concentration 2 hr after D-allulose administration. Plasma alkaline phosphatase activities showed a mild increase between 12 and 48 hr after D-allulose administration. These data suggested that a single oral dose of D-allulose does not show severe toxicity in dogs. The Japanese Society of Veterinary Science 2016-03-14 2016-06 /pmc/articles/PMC4937148/ /pubmed/26972334 http://dx.doi.org/10.1292/jvms.15-0676 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License.
spellingShingle Internal Medicine
NISHII, Naohito
NOMIZO, Toru
TAKASHIMA, Satoshi
MATSUBARA, Tatsuya
TOKUDA, Masaaki
KITAGAWA, Hitoshi
Single oral dose safety of D-allulose in dogs
title Single oral dose safety of D-allulose in dogs
title_full Single oral dose safety of D-allulose in dogs
title_fullStr Single oral dose safety of D-allulose in dogs
title_full_unstemmed Single oral dose safety of D-allulose in dogs
title_short Single oral dose safety of D-allulose in dogs
title_sort single oral dose safety of d-allulose in dogs
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937148/
https://www.ncbi.nlm.nih.gov/pubmed/26972334
http://dx.doi.org/10.1292/jvms.15-0676
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