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The pharmacological effects of intramuscular administration of alfaxalone combined with medetomidine and butorphanol in dogs
The pharmacological effects of intramuscular (IM) administration of alfaxalone combined with medetomidine and butorphanol were evaluated in 6 healthy beagle dogs. Each dog received three treatments with a minimum 10-day interval between treatments. The dogs received an IM injection of alfaxalone 2.5...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Veterinary Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937151/ https://www.ncbi.nlm.nih.gov/pubmed/26875835 http://dx.doi.org/10.1292/jvms.15-0159 |
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author | TAMURA, Jun HATAKEYAMA, Naohiro ISHIZUKA, Tomohito ITAMI, Takaharu FUKUI, Sho MIYOSHI, Kenjiro SANO, Tadashi PASLOSKE, Kirby YAMASHITA, Kazuto |
author_facet | TAMURA, Jun HATAKEYAMA, Naohiro ISHIZUKA, Tomohito ITAMI, Takaharu FUKUI, Sho MIYOSHI, Kenjiro SANO, Tadashi PASLOSKE, Kirby YAMASHITA, Kazuto |
author_sort | TAMURA, Jun |
collection | PubMed |
description | The pharmacological effects of intramuscular (IM) administration of alfaxalone combined with medetomidine and butorphanol were evaluated in 6 healthy beagle dogs. Each dog received three treatments with a minimum 10-day interval between treatments. The dogs received an IM injection of alfaxalone 2.5 mg/kg (ALFX), medetomidine 2.5 µg/kg and butorphanol 0.25 mg/kg (MB), or their combination (MBA) 1 hr after the recovery from their instrumentation. Endotracheal intubation was attempted, and dogs were allowed to breath room air. Neuro-depressive effects (behavior changes and subjective scores) and cardiorespiratory parameters (rectal temperature, heart rate, respiratory rate, direct blood pressure, central venous pressure and blood gases) were evaluated before and at 2 to 120 min after IM treatment. Each dog became lateral recumbency, except for two dogs administered the MB treatment. The duration was longer in the MBA treatment compared with the ALFX treatment (100 ± 48 min vs 46 ± 13 min). Maintenance of the endotracheal tube lasted for 60 ± 24 min in five dogs administered the MBA treatment and for 20 min in one dog administered the ALFX treatment. Cardiorespiratory variables were maintained within clinically acceptable ranges, although decreases in heart and respiratory rates, and increases in central venous pressure occurred after the MBA and MB treatments. The MBA treatment provided an anesthetic effect that permitted endotracheal intubation without severe cardiorespiratory depression in healthy dogs. |
format | Online Article Text |
id | pubmed-4937151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Japanese Society of Veterinary Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49371512016-07-11 The pharmacological effects of intramuscular administration of alfaxalone combined with medetomidine and butorphanol in dogs TAMURA, Jun HATAKEYAMA, Naohiro ISHIZUKA, Tomohito ITAMI, Takaharu FUKUI, Sho MIYOSHI, Kenjiro SANO, Tadashi PASLOSKE, Kirby YAMASHITA, Kazuto J Vet Med Sci Surgery The pharmacological effects of intramuscular (IM) administration of alfaxalone combined with medetomidine and butorphanol were evaluated in 6 healthy beagle dogs. Each dog received three treatments with a minimum 10-day interval between treatments. The dogs received an IM injection of alfaxalone 2.5 mg/kg (ALFX), medetomidine 2.5 µg/kg and butorphanol 0.25 mg/kg (MB), or their combination (MBA) 1 hr after the recovery from their instrumentation. Endotracheal intubation was attempted, and dogs were allowed to breath room air. Neuro-depressive effects (behavior changes and subjective scores) and cardiorespiratory parameters (rectal temperature, heart rate, respiratory rate, direct blood pressure, central venous pressure and blood gases) were evaluated before and at 2 to 120 min after IM treatment. Each dog became lateral recumbency, except for two dogs administered the MB treatment. The duration was longer in the MBA treatment compared with the ALFX treatment (100 ± 48 min vs 46 ± 13 min). Maintenance of the endotracheal tube lasted for 60 ± 24 min in five dogs administered the MBA treatment and for 20 min in one dog administered the ALFX treatment. Cardiorespiratory variables were maintained within clinically acceptable ranges, although decreases in heart and respiratory rates, and increases in central venous pressure occurred after the MBA and MB treatments. The MBA treatment provided an anesthetic effect that permitted endotracheal intubation without severe cardiorespiratory depression in healthy dogs. The Japanese Society of Veterinary Science 2016-02-11 2016-06 /pmc/articles/PMC4937151/ /pubmed/26875835 http://dx.doi.org/10.1292/jvms.15-0159 Text en ©2016 The Japanese Society of Veterinary Science http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. |
spellingShingle | Surgery TAMURA, Jun HATAKEYAMA, Naohiro ISHIZUKA, Tomohito ITAMI, Takaharu FUKUI, Sho MIYOSHI, Kenjiro SANO, Tadashi PASLOSKE, Kirby YAMASHITA, Kazuto The pharmacological effects of intramuscular administration of alfaxalone combined with medetomidine and butorphanol in dogs |
title | The pharmacological effects of intramuscular administration of alfaxalone combined with
medetomidine and butorphanol in dogs |
title_full | The pharmacological effects of intramuscular administration of alfaxalone combined with
medetomidine and butorphanol in dogs |
title_fullStr | The pharmacological effects of intramuscular administration of alfaxalone combined with
medetomidine and butorphanol in dogs |
title_full_unstemmed | The pharmacological effects of intramuscular administration of alfaxalone combined with
medetomidine and butorphanol in dogs |
title_short | The pharmacological effects of intramuscular administration of alfaxalone combined with
medetomidine and butorphanol in dogs |
title_sort | pharmacological effects of intramuscular administration of alfaxalone combined with
medetomidine and butorphanol in dogs |
topic | Surgery |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937151/ https://www.ncbi.nlm.nih.gov/pubmed/26875835 http://dx.doi.org/10.1292/jvms.15-0159 |
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