Physiological TLR5 expression in the intestine is regulated by differential DNA binding of Sp1/Sp3 through simultaneous Sp1 dephosphorylation and Sp3 phosphorylation by two different PKC isoforms

Toll-like receptor 5 (TLR5) expression in the intestinal epithelial cells (IECs) is critical to maintain health, as underscored by multiple intestinal and extra-intestinal diseases in mice genetically engineered for IEC-specific TLR5 knockout. A gradient of expression exists in the colonic epithelia...

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Detalles Bibliográficos
Autores principales: Thakur, Bhupesh Kumar, Dasgupta, Nirmalya, Ta, Atri, Das, Santasabuj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937308/
https://www.ncbi.nlm.nih.gov/pubmed/27060138
http://dx.doi.org/10.1093/nar/gkw189

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