Increased cytoplasmic TARDBP mRNA in affected spinal motor neurons in ALS caused by abnormal autoregulation of TDP-43

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disorder. In motor neurons of ALS, TAR DNA binding protein-43 (TDP-43), a nuclear protein encoded by TARDBP, is absent from the nucleus and forms cytoplasmic inclusions. TDP-43 auto-regulates the amount by regulating the TARDBP mRNA, which...

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Detalles Bibliográficos
Autores principales: Koyama, Akihide, Sugai, Akihiro, Kato, Taisuke, Ishihara, Tomohiko, Shiga, Atsushi, Toyoshima, Yasuko, Koyama, Misaki, Konno, Takuya, Hirokawa, Sachiko, Yokoseki, Akio, Nishizawa, Masatoyo, Kakita, Akiyoshi, Takahashi, Hitoshi, Onodera, Osamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937342/
https://www.ncbi.nlm.nih.gov/pubmed/27257061
http://dx.doi.org/10.1093/nar/gkw499

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