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Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb
Information processing in early sensory regions is modulated by a diverse range of inhibitory interneurons. We sought to elucidate the role of olfactory bulb interneurons called granule cells (GCs) in odor processing by imaging the activity of hundreds of these cells simultaneously in mice. Odor res...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937346/ https://www.ncbi.nlm.nih.gov/pubmed/27388949 http://dx.doi.org/10.1038/srep29308 |
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author | Wienisch, Martin Murthy, Venkatesh N. |
author_facet | Wienisch, Martin Murthy, Venkatesh N. |
author_sort | Wienisch, Martin |
collection | PubMed |
description | Information processing in early sensory regions is modulated by a diverse range of inhibitory interneurons. We sought to elucidate the role of olfactory bulb interneurons called granule cells (GCs) in odor processing by imaging the activity of hundreds of these cells simultaneously in mice. Odor responses in GCs were temporally diverse and spatially disperse, with some degree of non-random, modular organization. The overall sparseness of activation of GCs was highly correlated with the extent of glomerular activation by odor stimuli. Increasing concentrations of single odorants led to proportionately larger population activity, but some individual GCs had non-monotonic relations to concentration due to local inhibitory interactions. Individual dendritic segments could sometimes respond independently to odors, revealing their capacity for compartmentalized signaling in vivo. Collectively, the response properties of GCs point to their role in specific and local processing, rather than global operations such as response normalization proposed for other interneurons. |
format | Online Article Text |
id | pubmed-4937346 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-49373462016-07-13 Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb Wienisch, Martin Murthy, Venkatesh N. Sci Rep Article Information processing in early sensory regions is modulated by a diverse range of inhibitory interneurons. We sought to elucidate the role of olfactory bulb interneurons called granule cells (GCs) in odor processing by imaging the activity of hundreds of these cells simultaneously in mice. Odor responses in GCs were temporally diverse and spatially disperse, with some degree of non-random, modular organization. The overall sparseness of activation of GCs was highly correlated with the extent of glomerular activation by odor stimuli. Increasing concentrations of single odorants led to proportionately larger population activity, but some individual GCs had non-monotonic relations to concentration due to local inhibitory interactions. Individual dendritic segments could sometimes respond independently to odors, revealing their capacity for compartmentalized signaling in vivo. Collectively, the response properties of GCs point to their role in specific and local processing, rather than global operations such as response normalization proposed for other interneurons. Nature Publishing Group 2016-07-08 /pmc/articles/PMC4937346/ /pubmed/27388949 http://dx.doi.org/10.1038/srep29308 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Wienisch, Martin Murthy, Venkatesh N. Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
title | Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
title_full | Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
title_fullStr | Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
title_full_unstemmed | Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
title_short | Population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
title_sort | population imaging at subcellular resolution supports specific and local inhibition by granule cells in the olfactory bulb |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937346/ https://www.ncbi.nlm.nih.gov/pubmed/27388949 http://dx.doi.org/10.1038/srep29308 |
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