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Cathepsin S attenuates endosomal EGFR signalling: A mechanical rationale for the combination of cathepsin S and EGFR tyrosine kinase inhibitors

EGF-mediated EGFR endocytosis plays a crucial role in the attenuation of EGFR activation by sorting from early endosomes to late endosomes and transporting them into lysosomes for the final proteolytic degradation. We previously observed that cathepsin S (CTSS) inhibition induces tumour cell autopha...

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Detalles Bibliográficos
Autores principales:	Huang, Chien-Chang, Lee, Cheng-Che, Lin, Hsiao-Han, Chang, Jang-Yang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937378/ https://www.ncbi.nlm.nih.gov/pubmed/27387133 http://dx.doi.org/10.1038/srep29256

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