β-glucuronidase mRNA levels are correlated with gait and working memory in premutation females: understanding the role of FMR1 premutation alleles

Fragile X tremor ataxia syndrome (FXTAS) is a late-onset disorder manifesting in a proportion of FMR1 premutation individuals (PM: 55-199 CGG triplet expansions). FXTAS is associated with elevated levels of FMR1 mRNA which are toxic. In this study, relationships between neurocognitive and intra-step...

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Detalles Bibliográficos
Autores principales: Kraan, C. M., Cornish, K. M., Bui, Q. M., Li, X., Slater, H. R., Godler, D. E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937393/
https://www.ncbi.nlm.nih.gov/pubmed/27387142
http://dx.doi.org/10.1038/srep29366

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