Cargando…

Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome

Low progesterone levels are associated with luteal phase deficiency in women with polycystic ovary syndrome (PCOS). The mechanisms regulating progesterone biosynthesis in the granulosa cells from women with PCOS is largely unknown. Fractalkine is expressed in human ovaries, and is reported to regula...

Descripción completa

Detalles Bibliográficos
Autores principales: Huang, Shuo, Pang, Yanli, Yan, Jie, Lin, Shengli, Zhao, Yue, Lei, Li, Yan, Liying, Li, Rong, Ma, Caihong, Qiao, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937398/
https://www.ncbi.nlm.nih.gov/pubmed/27386819
http://dx.doi.org/10.1038/srep26205
_version_ 1782441705983705088
author Huang, Shuo
Pang, Yanli
Yan, Jie
Lin, Shengli
Zhao, Yue
Lei, Li
Yan, Liying
Li, Rong
Ma, Caihong
Qiao, Jie
author_facet Huang, Shuo
Pang, Yanli
Yan, Jie
Lin, Shengli
Zhao, Yue
Lei, Li
Yan, Liying
Li, Rong
Ma, Caihong
Qiao, Jie
author_sort Huang, Shuo
collection PubMed
description Low progesterone levels are associated with luteal phase deficiency in women with polycystic ovary syndrome (PCOS). The mechanisms regulating progesterone biosynthesis in the granulosa cells from women with PCOS is largely unknown. Fractalkine is expressed in human ovaries, and is reported to regulate progesterone production in granulosa cells of healthy women. In the current study, we aimed to examine the role of fractalkine in women with PCOS. Reduced fractalkine levels were found in follicular fluid and granulosa cells, accompanied by decreased progesterone production and reduced steroidogenic acute regulatory protein (StAR) expression in the granulosa cells of patients with PCOS. Administration of fractalkine reversed the inhibition of progesterone and StAR expression. The mechanism mediating these effects may be associated with the inhibition of ERK activity in the granulosa cells from women with PCOS. Our findings revealed that fractalkine regulated steroidogenesis in follicular granulosa cells of women with PCOS.
format Online
Article
Text
id pubmed-4937398
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-49373982016-07-13 Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome Huang, Shuo Pang, Yanli Yan, Jie Lin, Shengli Zhao, Yue Lei, Li Yan, Liying Li, Rong Ma, Caihong Qiao, Jie Sci Rep Article Low progesterone levels are associated with luteal phase deficiency in women with polycystic ovary syndrome (PCOS). The mechanisms regulating progesterone biosynthesis in the granulosa cells from women with PCOS is largely unknown. Fractalkine is expressed in human ovaries, and is reported to regulate progesterone production in granulosa cells of healthy women. In the current study, we aimed to examine the role of fractalkine in women with PCOS. Reduced fractalkine levels were found in follicular fluid and granulosa cells, accompanied by decreased progesterone production and reduced steroidogenic acute regulatory protein (StAR) expression in the granulosa cells of patients with PCOS. Administration of fractalkine reversed the inhibition of progesterone and StAR expression. The mechanism mediating these effects may be associated with the inhibition of ERK activity in the granulosa cells from women with PCOS. Our findings revealed that fractalkine regulated steroidogenesis in follicular granulosa cells of women with PCOS. Nature Publishing Group 2016-07-08 /pmc/articles/PMC4937398/ /pubmed/27386819 http://dx.doi.org/10.1038/srep26205 Text en Copyright © 2016, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Huang, Shuo
Pang, Yanli
Yan, Jie
Lin, Shengli
Zhao, Yue
Lei, Li
Yan, Liying
Li, Rong
Ma, Caihong
Qiao, Jie
Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome
title Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome
title_full Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome
title_fullStr Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome
title_full_unstemmed Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome
title_short Fractalkine restores the decreased expression of StAR and progesterone in granulosa cells from patients with polycystic ovary syndrome
title_sort fractalkine restores the decreased expression of star and progesterone in granulosa cells from patients with polycystic ovary syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937398/
https://www.ncbi.nlm.nih.gov/pubmed/27386819
http://dx.doi.org/10.1038/srep26205
work_keys_str_mv AT huangshuo fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT pangyanli fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT yanjie fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT linshengli fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT zhaoyue fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT leili fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT yanliying fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT lirong fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT macaihong fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome
AT qiaojie fractalkinerestoresthedecreasedexpressionofstarandprogesteroneingranulosacellsfrompatientswithpolycysticovarysyndrome