Caspase-3 dependent nitrergic neuronal apoptosis following cavernous nerve injury is mediated via RhoA and ROCK activation in major pelvic ganglion

Axonal injury due to prostatectomy leads to Wallerian degeneration of the cavernous nerve (CN) and erectile dysfunction (ED). Return of potency is dependent on axonal regeneration and reinnervation of the penis. Following CN injury (CNI), RhoA and Rho-associated protein kinase (ROCK) increase in pen...

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Autores principales: Hannan, Johanna L., Matsui, Hotaka, Sopko, Nikolai A., Liu, Xiaopu, Weyne, Emmanuel, Albersen, Maarten, Watson, Joseph W., Hoke, Ahmet, Burnett, Arthur L., Bivalacqua, Trinity J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937405/
https://www.ncbi.nlm.nih.gov/pubmed/27388816
http://dx.doi.org/10.1038/srep29416

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