Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer

Gastric cancer, highly dependent on tumor angiogenesis, causes uncontrolled lethality, in part due to chemoresistance. Here, we demonstrate that linifanib (ABT-869), a novel multi-targeted receptor tyrosine kinase inhibitor, markedly augments cytotoxicity of chemotherapies in human gastric cancer. A...

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Detalles Bibliográficos
Autores principales: Chen, Jing, Guo, Jiawei, Chen, Zhi, Wang, Jieqiong, Liu, Mingyao, Pang, Xiufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937412/
https://www.ncbi.nlm.nih.gov/pubmed/27387652
http://dx.doi.org/10.1038/srep29382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937412/
https://www.ncbi.nlm.nih.gov/pubmed/27387652
http://dx.doi.org/10.1038/srep29382

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