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Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer

Gastric cancer, highly dependent on tumor angiogenesis, causes uncontrolled lethality, in part due to chemoresistance. Here, we demonstrate that linifanib (ABT-869), a novel multi-targeted receptor tyrosine kinase inhibitor, markedly augments cytotoxicity of chemotherapies in human gastric cancer. A...

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Detalles Bibliográficos
Autores principales:	Chen, Jing, Guo, Jiawei, Chen, Zhi, Wang, Jieqiong, Liu, Mingyao, Pang, Xiufeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937412/ https://www.ncbi.nlm.nih.gov/pubmed/27387652 http://dx.doi.org/10.1038/srep29382

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