Selection and explosive growth alter genetic architecture and hamper the detection of causal rare variants

The role of rare alleles in complex phenotypes has been hotly debated, but most rare variant association tests (RVATs) do not account for the evolutionary forces that affect genetic architecture. Here, we use simulation and numerical algorithms to show that explosive population growth, as experience...

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Detalles Bibliográficos
Autores principales: Uricchio, Lawrence H., Zaitlen, Noah A., Ye, Chun Jimmie, Witte, John S., Hernandez, Ryan D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937562/
https://www.ncbi.nlm.nih.gov/pubmed/27197206
http://dx.doi.org/10.1101/gr.202440.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937562/
https://www.ncbi.nlm.nih.gov/pubmed/27197206
http://dx.doi.org/10.1101/gr.202440.115

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