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Basset: learning the regulatory code of the accessible genome with deep convolutional neural networks

The complex language of eukaryotic gene expression remains incompletely understood. Despite the importance suggested by many noncoding variants statistically associated with human disease, nearly all such variants have unknown mechanisms. Here, we address this challenge using an approach based on a...

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Detalles Bibliográficos
Autores principales: Kelley, David R., Snoek, Jasper, Rinn, John L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937568/
https://www.ncbi.nlm.nih.gov/pubmed/27197224
http://dx.doi.org/10.1101/gr.200535.115