Cargando…

Early changes in the metabolic profile of activated CD8(+) T cells

BACKGROUND: Antigenic stimulation of the T cell receptor (TCR) initiates a change from a resting state into an activated one, which ultimately results in proliferation and the acquisition of effector functions. To accomplish this task, T cells require dramatic changes in metabolism. Therefore, we in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cammann, Clemens, Rath, Alexander, Reichl, Udo, Lingel, Holger, Brunner-Weinzierl, Monika, Simeoni, Luca, Schraven, Burkhart, Lindquist, Jonathan A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937576/ https://www.ncbi.nlm.nih.gov/pubmed/27387758 http://dx.doi.org/10.1186/s12860-016-0104-x

Ejemplares similares

PAG/Cbp suppression reveals a contribution of CTLA-4 to setting the activation threshold in T cells
por: Smida, Michal, et al.
Publicado: (2013)

Migration of Th1 Lymphocytes Is Regulated by CD152 (CTLA-4)-Mediated Signaling via PI3 Kinase-Dependent Akt Activation
por: Knieke, Karin, et al.
Publicado: (2012)

IL‐13 determines specific IgE responses and SARS‐CoV‐2 immunity after mild COVID‐19 and novel mRNA vaccination
por: Meltendorf, Stefan, et al.
Publicado: (2022)

Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy
por: Bommhardt, Ursula, et al.
Publicado: (2019)

PD-1 limits differentiation and plasticity of Tc17 cells
por: Arra, Aditya, et al.
Publicado: (2023)

TCR-triggered extracellular superoxide production is not required for T-cell activation
por: Belikov, Aleksey V, et al.
Publicado: (2014)

T cells and reactive oxygen species
por: Belikov, Aleksey V., et al.
Publicado: (2015)

Selective targeting of transforming growth factor-beta1 into TCR/CD28 signalling plasma membrane domains silences T cell activation
por: Harder, Thomas, et al.
Publicado: (2014)

LIME: A New Membrane Raft-associated Adaptor Protein Involved in CD4 and CD8 Coreceptor Signaling
por: Brdičková, Naděžda, et al.
Publicado: (2003)

miR-20a Inhibits TCR-Mediated Signaling and Cytokine Production in Human Naïve CD4(+) T Cells
por: Reddycherla, Amarendra V., et al.
Publicado: (2015)

T cell-specific constitutive active SHP2 enhances T cell memory formation and reduces T cell activation
por: Cammann, Clemens, et al.
Publicado: (2022)

TCR activation kinetics and feedback regulation in primary human T cells
por: Poltorak, Mateusz, et al.
Publicado: (2013)

PD-1/PD-L1 Control of Antigen-Specifically Activated CD4 T-Cells of Neonates
por: Majer, Christiane, et al.
Publicado: (2023)

The Activity and Stability of p56Lck and TCR Signaling Do Not Depend on the Co-Chaperone Cdc37
por: Kowallik, Sarah, et al.
Publicado: (2020)

Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseases
por: Brunner-Weinzierl, Monika C, et al.
Publicado: (2004)

A Logical Model Provides Insights into T Cell Receptor Signaling
por: Saez-Rodriguez, Julio, et al.
Publicado: (2007)

An integrated proteome and transcriptome of B cell maturation defines poised activation states of transitional and mature B cells
por: Salerno, Fiamma, et al.
Publicado: (2023)

The Transmembrane Adaptor Protein SIT Inhibits TCR-Mediated Signaling
por: Arndt, Börge, et al.
Publicado: (2011)

A highly conserved redox-active Mx((2))CWx((6))R motif regulates Zap70 stability and activity
por: Thurm, Christoph, et al.
Publicado: (2017)

Pitavastatin Is a Highly Potent Inhibitor of T-Cell Proliferation
por: Voss, Linda, et al.
Publicado: (2021)

Immune-checkpoint blockade of CTLA-4 (CD152) in antigen-specific human T-cell responses differs profoundly between neonates, children, and adults
por: Arra, Aditya, et al.
Publicado: (2021)

Type of PaperY192 within the SH2 Domain of Lck Regulates TCR Signaling Downstream of PLC-γ1 and Thymic Selection
por: Kästle, Matthias, et al.
Publicado: (2022)

Tyrosine 192 within the SH2 domain of the Src-protein tyrosine kinase p56(Lck) regulates T-cell activation independently of Lck/CD45 interactions
por: Kästle, Matthias, et al.
Publicado: (2020)

CTLA-4-mediated posttranslational modifications direct cytotoxic T-lymphocyte differentiation
por: Lingel, Holger, et al.
Publicado: (2017)

CD152 (CTLA-4) Determines CD4 T Cell Migration In Vitro and In Vivo
por: Knieke, Karin, et al.
Publicado: (2009)

Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K(v)1.3 potassium channels, AKT and ERK1/2 signaling
por: Lowinus, Theresa, et al.
Publicado: (2019)

Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains Differentially Modulates Src Kinase Activity in Brain Maturation
por: Lindquist, Sabine, et al.
Publicado: (2011)

A Cysteine Residue within the Kinase Domain of Zap70 Regulates Lck Activity and Proximal TCR Signaling
por: Schultz, Annika, et al.
Publicado: (2022)

Bifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood
por: Vogel, Katrin, et al.
Publicado: (2023)

Preventing Atopic Diseases During Childhood – Early Exposure Matters
por: Pierau, Mandy, et al.
Publicado: (2021)

Metabolic effects of influenza virus infection in cultured animal cells: Intra- and extracellular metabolite profiling
por: Ritter, Joachim B, et al.
Publicado: (2010)

Unique autoantibody prevalence in long-term recovered SARS-CoV-2-infected individuals
por: Lingel, Holger, et al.
Publicado: (2021)

The Multiple Roles of the Cytosolic Adapter Proteins ADAP, SKAP1 and SKAP2 for TCR/CD3 -Mediated Signaling Events
por: Dadwal, Nirdosh, et al.
Publicado: (2021)

Simulated Evolution of Signal Transduction Networks
por: Mobashir, Mohammad, et al.
Publicado: (2012)

ABC Transporters in T Cell-Mediated Physiological and Pathological Immune Responses
por: Thurm, Christoph, et al.
Publicado: (2021)

Metabolic Interdependency of Th2 Cell-Mediated Type 2 Immunity and the Tumor Microenvironment
por: Schreiber, Simon, et al.
Publicado: (2021)

Signaling Signatures and Functional Properties of Anti-Human CD28 Superagonistic Antibodies
por: Waibler, Zoe, et al.
Publicado: (2008)

CTLA-4 and PD-1 Control of T-Cell Motility and Migration: Implications for Tumor Immunotherapy
por: Brunner-Weinzierl, Monika C., et al.
Publicado: (2018)

Allgemeine Kenntnisse zu häufig angewandten Testverfahren in der rheumatologisch-immunologischen Diagnostik und Forschung
por: Reinhold, Dirk, et al.
Publicado: (2023)

Lactate exposure shapes the metabolic and transcriptomic profile of CD8+ T cells
por: Barbieri, Laura, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_4m1c7c3urru2o6etn42tnn53ra