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Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations

BACKGROUND: Due to therapeutic implications with regard to both efficiency and safety of chemotherapy agents it is important to differentiate between subtypes of NSCLC. Up to today we experience a continuous reservation regarding the use of fine needle aspiration cytology. The aim of the present stu...

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Autores principales: Biancosino, Christian, Krüger, Marcus, Vollmer, Ekkehard, Welker, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937589/
https://www.ncbi.nlm.nih.gov/pubmed/27388913
http://dx.doi.org/10.1186/s13000-016-0510-6
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author Biancosino, Christian
Krüger, Marcus
Vollmer, Ekkehard
Welker, Lutz
author_facet Biancosino, Christian
Krüger, Marcus
Vollmer, Ekkehard
Welker, Lutz
author_sort Biancosino, Christian
collection PubMed
description BACKGROUND: Due to therapeutic implications with regard to both efficiency and safety of chemotherapy agents it is important to differentiate between subtypes of NSCLC. Up to today we experience a continuous reservation regarding the use of fine needle aspiration cytology. The aim of the present study is to estimate the value of cytologic criteria for lung cancer typing on small biopsies independent from all possible technique failures. METHODS: Between January 1997 and December 2008 760 intraoperative FNAC- (fine needle aspiration cytology) specimens from 702 patients have been examined. Cytologic evaluation and immediate communication of results to the surgeons followed. Afterwards, intraoperative cytologic findings were compared with final histologic diagnoses of the resected specimens. RESULTS: Intraoperative cytologic analysis yielded a sensitivity of 94.8 %, a specificity of 98.8 %. An overall positive predictive value of 99.8 % with respect to final histologic analysis of primary lung cancer was achieved. The highest value could be reached for adenocarcinomas, followed by carcinoids and squamous cell carcinomas. CONCLUSIONS: Lung cancer typing according to cytologic criteria is feasible and accurate as well as comparable with results of histologic analysis on small specimens. Herewith, clinicians can come up to the increasing demands on minimally invasive harvested specimens with regard to therapeutic implications.
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spelling pubmed-49375892016-07-09 Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations Biancosino, Christian Krüger, Marcus Vollmer, Ekkehard Welker, Lutz Diagn Pathol Research BACKGROUND: Due to therapeutic implications with regard to both efficiency and safety of chemotherapy agents it is important to differentiate between subtypes of NSCLC. Up to today we experience a continuous reservation regarding the use of fine needle aspiration cytology. The aim of the present study is to estimate the value of cytologic criteria for lung cancer typing on small biopsies independent from all possible technique failures. METHODS: Between January 1997 and December 2008 760 intraoperative FNAC- (fine needle aspiration cytology) specimens from 702 patients have been examined. Cytologic evaluation and immediate communication of results to the surgeons followed. Afterwards, intraoperative cytologic findings were compared with final histologic diagnoses of the resected specimens. RESULTS: Intraoperative cytologic analysis yielded a sensitivity of 94.8 %, a specificity of 98.8 %. An overall positive predictive value of 99.8 % with respect to final histologic analysis of primary lung cancer was achieved. The highest value could be reached for adenocarcinomas, followed by carcinoids and squamous cell carcinomas. CONCLUSIONS: Lung cancer typing according to cytologic criteria is feasible and accurate as well as comparable with results of histologic analysis on small specimens. Herewith, clinicians can come up to the increasing demands on minimally invasive harvested specimens with regard to therapeutic implications. BioMed Central 2016-07-07 /pmc/articles/PMC4937589/ /pubmed/27388913 http://dx.doi.org/10.1186/s13000-016-0510-6 Text en © The Author(s). 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Biancosino, Christian
Krüger, Marcus
Vollmer, Ekkehard
Welker, Lutz
Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
title Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
title_full Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
title_fullStr Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
title_full_unstemmed Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
title_short Intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
title_sort intraoperative fine needle aspirations - diagnosis and typing of lung cancer in small biopsies: challenges and limitations
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937589/
https://www.ncbi.nlm.nih.gov/pubmed/27388913
http://dx.doi.org/10.1186/s13000-016-0510-6
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