Pharmacokinetics, safety, and tolerability following single-dose migalastat hydrochloride (GR181413A/AT1001) in healthy male Japanese subjects

OBJECTIVE: Fabry disease is a rare X-linked disease caused by mutations to the GLA gene, resulting in a deficiency of the lysosomal enzyme alpha-galactosidase A. This study evaluated the pharmacokinetics, safety, and tolerability of ascending single doses of oral migalastat hydrochloride (HCl), an i...

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Detalles Bibliográficos
Autores principales: Ino, Hiroko, Takahashi, Naoki, Terao, Takumi, Mudd, Paul N., Hirama, Toshiyasu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Maney Publishing 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937648/
https://www.ncbi.nlm.nih.gov/pubmed/27536442
http://dx.doi.org/10.3109/21556660.2013.827117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937648/
https://www.ncbi.nlm.nih.gov/pubmed/27536442
http://dx.doi.org/10.3109/21556660.2013.827117

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