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Pharmacokinetics, safety, and tolerability following single-dose migalastat hydrochloride (GR181413A/AT1001) in healthy male Japanese subjects

OBJECTIVE: Fabry disease is a rare X-linked disease caused by mutations to the GLA gene, resulting in a deficiency of the lysosomal enzyme alpha-galactosidase A. This study evaluated the pharmacokinetics, safety, and tolerability of ascending single doses of oral migalastat hydrochloride (HCl), an i...

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Detalles Bibliográficos
Autores principales:	Ino, Hiroko, Takahashi, Naoki, Terao, Takumi, Mudd, Paul N., Hirama, Toshiyasu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Maney Publishing 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937648/ https://www.ncbi.nlm.nih.gov/pubmed/27536442 http://dx.doi.org/10.3109/21556660.2013.827117

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