Cargando…

Effects of dalfampridine and its metabolites on cloned human potassium channels K(v) 1.1, K(v) 1.2, and K(v) 1.4 expressed in human embryonic kidney cells

BACKGROUND: Dalfampridine (4-aminopyridine; 4-AP) is a potassium channel blocker that has been available in the United States as a treatment to improve walking in patients with multiple sclerosis. 4-AP is well-characterized in vitro with regard to inhibition of neuronal potassium channels, but the p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Caggiano, Anthony, Blight, Andrew, Parry, Tom J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Maney Publishing 2013
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937658/ https://www.ncbi.nlm.nih.gov/pubmed/27536438 http://dx.doi.org/10.3109/21556660.2013.791623

Ejemplares similares

Identification of metabolites of dalfampridine (4-aminopyridine) in dog and rat
por: Caggiano, Anthony, et al.
Publicado: (2013)

Identification of metabolites of dalfampridine (4-aminopyridine) in human subjects and reaction phenotyping of relevant cytochrome P450 pathways
por: Caggiano, Anthony, et al.
Publicado: (2013)

Imiquimod enhances excitability of dorsal root ganglion neurons by inhibiting background (K(2P)) and voltage-gated (K(v)1.1 and K(v)1.2) potassium channels
por: Lee, Jaekwang, et al.
Publicado: (2012)

An epilepsy-associated K(V)1.2 charge-transfer-center mutation impairs K(V)1.2 and K(V)1.4 trafficking
por: Nilsson, Michelle, et al.
Publicado: (2022)

Tuning Scorpion Toxin Selectivity: Switching From K(V)1.1 to K(V)1.3
por: Gigolaev, Andrei M., et al.
Publicado: (2020)

K-p cross sections between 1.1 and 1.4 GeV/c
por: Griselin, J, et al.
Publicado: (1975)

K(V)1 and K(V)3 Potassium Channels Identified at Presynaptic Terminals of the Corticostriatal Synapses in Rat
por: Meneses, David, et al.
Publicado: (2016)

Homology modeling of a voltage-gated potassium channel (human K(v)7.1)
por: Goncearenco, Alexandr, et al.
Publicado: (2007)

Inverse Modulation of Neuronal K(v)12.1 and K(v)11.1 Channels by 4-Aminopyridine and NS1643
por: Dierich, Marlen, et al.
Publicado: (2018)

K(V)1.5–K(V)β1.3 Recycling Is PKC-Dependent
por: Macias, Alvaro, et al.
Publicado: (2021)

Precision measurement of the K-p→K̅0n cross section below 1.1 GeV/c
por: Alston-Garnjost, M, et al.
Publicado: (1977)

Proposal for an extension of the 1.0 - 1.4 GeV/c K$^{-}$ experiment
por: CERN. Geneva. Track Chamber Committee
Publicado: (1972)

K(V)11.1, Na(V)1.5, and Ca(V)1.2 Transporter Proteins as Antitarget for Drug Cardiotoxicity
por: Kowalska, Magdalena, et al.
Publicado: (2020)

Inhibition of K(Ca)2 and K(v)11.1 Channels in Pigs With Left Ventricular Dysfunction
por: Citerni, Carlotta, et al.
Publicado: (2020)

A proposal to study $K^{+}p$ and $K^{+}d$ processes in the momentum range 1.1 - 1.5 GeV/c
por: CERN. Geneva. Track Chamber Committee
Publicado: (1966)

Contribution of the Potassium Channels K(V)1.3 and K(Ca)3.1 to Smooth Muscle Cell Proliferation in Growing Collateral Arteries
por: Lasch, Manuel, et al.
Publicado: (2020)

Celebrities in the heart, strangers in the pancreatic beta cell: Voltage‐gated potassium channels K(v)7.1 and K(v)11.1 bridge long QT syndrome with hyperinsulinaemia as well as type 2 diabetes
por: Lubberding, Anniek F., et al.
Publicado: (2022)

Rapid Internalization of the Oncogenic K(+) Channel K(V)10.1
por: Kohl, Tobias, et al.
Publicado: (2011)

Structures of wild-type and H451N mutant human lymphocyte potassium channel K(V)1.3
por: Liu, Sanling, et al.
Publicado: (2021)

Block of K(v)1.7 potassium currents increases glucose-stimulated insulin secretion
por: Finol-Urdaneta, Rocio K, et al.
Publicado: (2012)

PIST (GOPC) modulates the oncogenic voltage-gated potassium channel K(V)10.1
por: Herrmann, Solveig, et al.
Publicado: (2013)

Cortactin Controls Surface Expression of the Voltage-gated Potassium Channel K(V)10.1
por: Herrmann, Solveig, et al.
Publicado: (2012)

In vivo imaging of tumour xenografts with an antibody targeting the potassium channel K(v)10.1
por: Napp, Joanna, et al.
Publicado: (2016)

Independent movement of the voltage sensors in K(V)2.1/K(V)6.4 heterotetramers
por: Bocksteins, Elke, et al.
Publicado: (2017)

Present status of the 1.5 GeV/c K-meson beam K 1
por: Cooper, A W, et al.
Publicado: (1961)

Search for strange $(S = -2)$ dibaryons in the reaction $K^{-} + d \rightarrow K^{+} + MM$ at 1.4 GeV/c
por: D'Agostini, Giulio, et al.
Publicado: (1982)

Evidence for three $ K\pi \pi $ resonant states below 1.4 GeV in $ K^{+} p $ reactions at 5 GeV/c
por: Bassompierre, Gabriel, et al.
Publicado: (1967)

Observation of a $K\overline{K}$ enhancement at 1.85 GeV in the reaction $K^- p \to K\overline{K}\Lambda$ at 8.25 GeV/c
por: Al-Harran, S, et al.
Publicado: (1981)

Identification of a key residue in K(v)7.1 potassium channel essential for sensing external potassium ions
por: Wang, Wenying, et al.
Publicado: (2015)

Editing of human K(V)1.1 channel mRNAs disrupts binding of the N-terminus tip at the intracellular cavity
por: Gonzalez, Carlos, et al.
Publicado: (2011)

Altered gating of K(v)1.4 in the nucleus accumbens suppresses motivation for reward
por: O'Donovan, Bernadette, et al.
Publicado: (2019)

Fludarabine Inhibits K(V)1.3 Currents in Human B Lymphocytes
por: de la Cruz, Alicia, et al.
Publicado: (2017)

The voltage-gated potassium channel K(V)1.3 regulates neutrophil recruitment during inflammation
por: Immler, Roland, et al.
Publicado: (2021)

K(V)1/D‐type potassium channels inhibit the excitability of bronchopulmonary vagal afferent nerves
por: Sun, Hui, et al.
Publicado: (2022)

Dysfunction of the Heteromeric K(V)7.3/K(V)7.5 Potassium Channel is Associated with Autism Spectrum Disorders
por: Gilling, Mette, et al.
Publicado: (2013)

K(V)11.1 Potassium Channel and the Na(+)/H(+) Antiporter NHE1 Modulate Adhesion-Dependent Intracellular pH in Colorectal Cancer Cells
por: Iorio, Jessica, et al.
Publicado: (2020)

Expression and differential distribution of the shaker-related voltage-gated potassium channel family (K(V)1.x) in human hippocampus and neocortex
por: Leitner, Irmgard, et al.
Publicado: (2011)

The Activity of K(V)11.1 Potassium Channel Modulates F-Actin Organization During Cell Migration of Pancreatic Ductal Adenocarcinoma Cells
por: Manoli, Sagar, et al.
Publicado: (2019)

A study of the K0$_{1}$K0$_{1}$ system centrally produced in the reactions pi+p --> pi+(K0$_{1}$K0$_{1}$)p and pp --> p(K0$_{1}$K0$_{1}$)p at 85 GeV/c
por: Armstrong, T A, et al.
Publicado: (1985)

Study of the $K^{+}K^{-}$ pairs from the reaction $\pi{-}p \rightarrow K^{+} K^{-}n$ at 11 GeV/c
por: Dietl, H, et al.
Publicado: (1969)

Cannot write session to /tmp/vufind_sessions/sess_vsvnp6ldqed3dekd0gn088741s