The C677T variant in MTHFR modulates associations between blood-based and cerebrospinal fluid biomarkers of neurodegeneration

The C677T functional variant in the methylene-tetrahydrofolate reductase (MTHFR) gene results in reduced enzymatic activity and elevated blood levels of homocysteine. Plasma levels of apolipoprotein E (ApoE) are negatively correlated with cerebral amyloid burden, but plasma homocysteine concentratio...

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Detalles Bibliográficos
Autores principales: Roussotte, Florence F., Narr, Katherine L., Small, Gary W., Thompson, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2016
Materias:
Clinical Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937804/
https://www.ncbi.nlm.nih.gov/pubmed/27380243
http://dx.doi.org/10.1097/WNR.0000000000000636

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