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High Affinity Dopamine D(3) Receptor (D(3)R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D(3)R Knockout Mice

[Image: see text] The dopamine D(3) receptor (D(3)R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D(3)R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevertheless, poor bioavailabili...

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Detalles Bibliográficos
Autores principales: Boateng, Comfort A., Bakare, Oluyomi M., Zhan, Jia, Banala, Ashwini K., Burzynski, Caitlin, Pommier, Elie, Keck, Thomas M., Donthamsetti, Prashant, Javitch, Jonathan A., Rais, Rana, Slusher, Barbara S., Xi, Zheng-Xiong, Newman, Amy Hauck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2015
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937837/
https://www.ncbi.nlm.nih.gov/pubmed/26203768
http://dx.doi.org/10.1021/acs.jmedchem.5b00776
Descripción
Sumario:[Image: see text] The dopamine D(3) receptor (D(3)R) is a promising target for the development of pharmacotherapeutics to treat substance use disorders. Several D(3)R-selective antagonists are effective in animal models of drug abuse, especially in models of relapse. Nevertheless, poor bioavailability, metabolic instability, and/or predicted toxicity have impeded success in translating these drug candidates to clinical use. Herein, we report a series of D(3)R-selective 4-phenylpiperazines with improved metabolic stability. A subset of these compounds was evaluated for D(3)R functional efficacy and off-target binding at selected 5-HT receptor subtypes, where significant overlap in SAR with D(3)R has been observed. Several high affinity D(3)R antagonists, including compounds 16 (K(i) = 0.12 nM) and 32 (K(i) = 0.35 nM), showed improved metabolic stability compared to the parent compound, PG648 (6). Notably, 16 and the classic D(3)R antagonist SB277011A (2) were effective in reducing self-administration of heroin in wild-type but not D(3)R knockout mice.