Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure

BACKGROUND: High-content imaging (HCI) allows simultaneous measurement of multiple cellular phenotypic changes and is an important tool for evaluating the biological activity of chemicals. OBJECTIVES: Our goal was to analyze dynamic cellular changes using HCI to identify the “tipping point” at which...

Descripción completa

Detalles Bibliográficos
Autores principales: Shah, Imran, Setzer, R. Woodrow, Jack, John, Houck, Keith A., Judson, Richard S., Knudsen, Thomas B., Liu, Jie, Martin, Matthew T., Reif, David M., Richard, Ann M., Thomas, Russell S., Crofton, Kevin M., Dix, David J., Kavlock, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Environmental Health Sciences 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937847/
https://www.ncbi.nlm.nih.gov/pubmed/26473631
http://dx.doi.org/10.1289/ehp.1409029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937847/
https://www.ncbi.nlm.nih.gov/pubmed/26473631
http://dx.doi.org/10.1289/ehp.1409029

Ejemplares similares