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Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review
Stroke is a dramatic complication of pancreatic cancer with mechanisms related to oncological disease. A better description of the characteristics of cerebrovascular events would help better understand the pathogeny and protect vulnerable patients. We thus conducted a descriptive analysis of clinica...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937929/ https://www.ncbi.nlm.nih.gov/pubmed/27368015 http://dx.doi.org/10.1097/MD.0000000000004009 |
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author | Bonnerot, Mathieu Humbertjean, Lisa Mione, Gioia Lacour, Jean-Christophe Derelle, Anne-Laure Sanchez, Jean-Charles Riou-Comte, Nolwenn Richard, Sébastien |
author_facet | Bonnerot, Mathieu Humbertjean, Lisa Mione, Gioia Lacour, Jean-Christophe Derelle, Anne-Laure Sanchez, Jean-Charles Riou-Comte, Nolwenn Richard, Sébastien |
author_sort | Bonnerot, Mathieu |
collection | PubMed |
description | Stroke is a dramatic complication of pancreatic cancer with mechanisms related to oncological disease. A better description of the characteristics of cerebrovascular events would help better understand the pathogeny and protect vulnerable patients. We thus conducted a descriptive analysis of clinical, biological, and radiological features of patients from our centers and literature. We reviewed consecutive cases of patients who presented cerebrovascular events and pancreatic cancer in 4 stroke units in Lorrain (France) between January 1, 2009 and March 31, 2015, and all reported cases of literature. We identified 17 cases in our centers and 18 reported cases. Fifty-seven per cent of patients were male. Median age was 63 ± 14 years and ranged from 23 to 81 years. All cerebral events were ischemic. At the onset of stroke, pancreatic cancer had already been diagnosed in 59% of the patients in our centers for a mean time of 5.4 months. Five of them (29%) were being treated with gemcitabine and 2 (12%) with folfirinox. Adenocarcinoma at metastatic stage was reported in 82% of cases overall. Brain imaging revealed disseminated infarctions in 64%. High median levels of D-dimer (7600 ± 5 × 10(7) μg/L), C-reactive protein (63 ± 43 mg/L), and elevated prothrombin time (19 ± 6 seconds) were found. Thirty-six per cent of patients explored with echocardiography were diagnosed with nonbacterial thrombotic endocarditis. Ten of our patients received anticoagulant therapy as secondary stroke prevention without any documented recurrence. Nevertheless, outcome was poor with a median survival time of 28 ± 14 days after stroke onset. Cerebral ischemic events occur at advanced stages of pancreatic cancer, most likely by a thromboembolic mechanism. Disseminated infarctions and high D-dimer, C-reactive protein levels, and a high prothrombin time are the most constant characteristics found in this context. All patients should be screened for nonbacterial thrombotic endocarditis as this etiology supports the use of anticoagulant therapy. |
format | Online Article Text |
id | pubmed-4937929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-49379292016-08-18 Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review Bonnerot, Mathieu Humbertjean, Lisa Mione, Gioia Lacour, Jean-Christophe Derelle, Anne-Laure Sanchez, Jean-Charles Riou-Comte, Nolwenn Richard, Sébastien Medicine (Baltimore) 5300 Stroke is a dramatic complication of pancreatic cancer with mechanisms related to oncological disease. A better description of the characteristics of cerebrovascular events would help better understand the pathogeny and protect vulnerable patients. We thus conducted a descriptive analysis of clinical, biological, and radiological features of patients from our centers and literature. We reviewed consecutive cases of patients who presented cerebrovascular events and pancreatic cancer in 4 stroke units in Lorrain (France) between January 1, 2009 and March 31, 2015, and all reported cases of literature. We identified 17 cases in our centers and 18 reported cases. Fifty-seven per cent of patients were male. Median age was 63 ± 14 years and ranged from 23 to 81 years. All cerebral events were ischemic. At the onset of stroke, pancreatic cancer had already been diagnosed in 59% of the patients in our centers for a mean time of 5.4 months. Five of them (29%) were being treated with gemcitabine and 2 (12%) with folfirinox. Adenocarcinoma at metastatic stage was reported in 82% of cases overall. Brain imaging revealed disseminated infarctions in 64%. High median levels of D-dimer (7600 ± 5 × 10(7) μg/L), C-reactive protein (63 ± 43 mg/L), and elevated prothrombin time (19 ± 6 seconds) were found. Thirty-six per cent of patients explored with echocardiography were diagnosed with nonbacterial thrombotic endocarditis. Ten of our patients received anticoagulant therapy as secondary stroke prevention without any documented recurrence. Nevertheless, outcome was poor with a median survival time of 28 ± 14 days after stroke onset. Cerebral ischemic events occur at advanced stages of pancreatic cancer, most likely by a thromboembolic mechanism. Disseminated infarctions and high D-dimer, C-reactive protein levels, and a high prothrombin time are the most constant characteristics found in this context. All patients should be screened for nonbacterial thrombotic endocarditis as this etiology supports the use of anticoagulant therapy. Wolters Kluwer Health 2016-07-01 /pmc/articles/PMC4937929/ /pubmed/27368015 http://dx.doi.org/10.1097/MD.0000000000004009 Text en Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5300 Bonnerot, Mathieu Humbertjean, Lisa Mione, Gioia Lacour, Jean-Christophe Derelle, Anne-Laure Sanchez, Jean-Charles Riou-Comte, Nolwenn Richard, Sébastien Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review |
title | Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review |
title_full | Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review |
title_fullStr | Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review |
title_full_unstemmed | Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review |
title_short | Cerebral ischemic events in patients with pancreatic cancer: A retrospective cohort study of 17 patients and a literature review |
title_sort | cerebral ischemic events in patients with pancreatic cancer: a retrospective cohort study of 17 patients and a literature review |
topic | 5300 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4937929/ https://www.ncbi.nlm.nih.gov/pubmed/27368015 http://dx.doi.org/10.1097/MD.0000000000004009 |
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