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Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma
The epithelial cells of the lung are at the interface of a host and its environment and are therefore directly exposed to the inhaled air-borne particles. Rather than serving as a simple physical barrier, airway epithelia detect allergens and other irritants and then help organize the subsequent imm...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938024/ https://www.ncbi.nlm.nih.gov/pubmed/27377718 http://dx.doi.org/10.1098/rstb.2015.0424 |
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author | Samanta, Krishna Parekh, Anant B. |
author_facet | Samanta, Krishna Parekh, Anant B. |
author_sort | Samanta, Krishna |
collection | PubMed |
description | The epithelial cells of the lung are at the interface of a host and its environment and are therefore directly exposed to the inhaled air-borne particles. Rather than serving as a simple physical barrier, airway epithelia detect allergens and other irritants and then help organize the subsequent immune response through release of a plethora of secreted signals. Many of these signals are generated in response to opening of store-operated Ca(2+) channels in the plasma membrane. In this review, we describe the properties of airway store-operated channels and their role in regulating airway epithelial cell function. This article is part of the themed issue ‘Evolution brings Ca(2+) and ATP together to control life and death’. |
format | Online Article Text |
id | pubmed-4938024 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-49380242016-08-05 Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma Samanta, Krishna Parekh, Anant B. Philos Trans R Soc Lond B Biol Sci Articles The epithelial cells of the lung are at the interface of a host and its environment and are therefore directly exposed to the inhaled air-borne particles. Rather than serving as a simple physical barrier, airway epithelia detect allergens and other irritants and then help organize the subsequent immune response through release of a plethora of secreted signals. Many of these signals are generated in response to opening of store-operated Ca(2+) channels in the plasma membrane. In this review, we describe the properties of airway store-operated channels and their role in regulating airway epithelial cell function. This article is part of the themed issue ‘Evolution brings Ca(2+) and ATP together to control life and death’. The Royal Society 2016-08-05 /pmc/articles/PMC4938024/ /pubmed/27377718 http://dx.doi.org/10.1098/rstb.2015.0424 Text en © 2016 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Articles Samanta, Krishna Parekh, Anant B. Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma |
title | Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma |
title_full | Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma |
title_fullStr | Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma |
title_full_unstemmed | Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma |
title_short | Store-operated Ca(2+) channels in airway epithelial cell function and implications for asthma |
title_sort | store-operated ca(2+) channels in airway epithelial cell function and implications for asthma |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938024/ https://www.ncbi.nlm.nih.gov/pubmed/27377718 http://dx.doi.org/10.1098/rstb.2015.0424 |
work_keys_str_mv | AT samantakrishna storeoperatedca2channelsinairwayepithelialcellfunctionandimplicationsforasthma AT parekhanantb storeoperatedca2channelsinairwayepithelialcellfunctionandimplicationsforasthma |