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Conserved Sequence Preferences Contribute to Substrate Recognition by the Proteasome

The proteasome has pronounced preferences for the amino acid sequence of its substrates at the site where it initiates degradation. Here, we report that modulating these sequences can tune the steady-state abundance of proteins over 2 orders of magnitude in cells. This is the same dynamic range as s...

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Detalles Bibliográficos
Autores principales:	Yu, Houqing, Singh Gautam, Amit K., Wilmington, Shameika R., Wylie, Dennis, Martinez-Fonts, Kirby, Kago, Grace, Warburton, Marie, Chavali, Sreenivas, Inobe, Tomonao, Finkelstein, Ilya J., Babu, M. Madan, Matouschek, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Protein Synthesis and Degradation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938175/ https://www.ncbi.nlm.nih.gov/pubmed/27226608 http://dx.doi.org/10.1074/jbc.M116.727578

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