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The Precise Structures and Stereochemistry of Trihydroxy-linoleates Esterified in Human and Porcine Epidermis and Their Significance in Skin Barrier Function: IMPLICATION OF AN EPOXIDE HYDROLASE IN THE TRANSFORMATIONS OF LINOLEATE

Creation of an intact skin water barrier, a prerequisite for life on dry land, requires the lipoxygenase-catalyzed oxidation of the essential fatty acid linoleate, which is esterified to the ω-hydroxyl of an epidermis-specific ceramide. Oxidation of the linoleate moiety by lipoxygenases is proposed...

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Detalles Bibliográficos
Autores principales:	Chiba, Takahito, Thomas, Christopher P., Calcutt, M. Wade, Boeglin, William E., O'Donnell, Valerie B., Brash, Alan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2016
Materias:	Lipids
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938176/ https://www.ncbi.nlm.nih.gov/pubmed/27151221 http://dx.doi.org/10.1074/jbc.M115.711267

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