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Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population

BACKGROUND: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic. Studies linking Human Leukocyte Antigens (HLA) to AA have suggested...

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Autores principales: Barbosa, Ângela Marques, Prestes-Carneiro, Luiz Euribel, Sobral, Aldri Roberta Sodoschi, Sakiyama, Marcelo Jun, Lemos, Bruna Cerávolo, de Abreu, Marilda Aparecida Milanez Morgado, Martos, Luciana Leite Crivelin, Moliterno, Ricardo Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Dermatologia 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938270/
https://www.ncbi.nlm.nih.gov/pubmed/27438193
http://dx.doi.org/10.1590/abd1806-4841.20164250
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author Barbosa, Ângela Marques
Prestes-Carneiro, Luiz Euribel
Sobral, Aldri Roberta Sodoschi
Sakiyama, Marcelo Jun
Lemos, Bruna Cerávolo
de Abreu, Marilda Aparecida Milanez Morgado
Martos, Luciana Leite Crivelin
Moliterno, Ricardo Alberto
author_facet Barbosa, Ângela Marques
Prestes-Carneiro, Luiz Euribel
Sobral, Aldri Roberta Sodoschi
Sakiyama, Marcelo Jun
Lemos, Bruna Cerávolo
de Abreu, Marilda Aparecida Milanez Morgado
Martos, Luciana Leite Crivelin
Moliterno, Ricardo Alberto
author_sort Barbosa, Ângela Marques
collection PubMed
description BACKGROUND: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic. Studies linking Human Leukocyte Antigens (HLA) to AA have suggested that immunogenetic factors may play a role in the disease's onset/development. OBJECTIVES: To investigate an association between AA and HLA class I/II in white Brazilians. Methods: Patients and control groups comprised 33 and 112 individuals, respectively. DNA extraction was performed by column method with BioPur kit. Allele's classification was undertaken using the PCR-SSO technique. HLA frequencies were obtained through direct counting and subjected to comparison by means of the chi-square test. RESULTS: Most patients were aged over 16, with no familial history, and developed partial AA, with no recurrent episodes. Patients showed a higher frequency of HLA-B*40, HLA-B*45, HLA-B*53 and HLA-C*04 compared with controls, although P was not significant after Bonferroni correction. Regarding HLA class II, only HLA-DRB1*07 revealed statistical significance; nevertheless, it featured more prominently in controls than patients (P=0.04; Pc=0.52; OR=0.29; 95%; CI=0.07 to 1.25). P was not significant after Bonferroni correction. CONCLUSIONS: The development of AA does not seem to be associated with HLA in white Brazilians, nor with susceptibility or resistance. The studies were carried out in populations with little or no miscegenation, unlike the Brazilian population in general, which could explain the inconsistency found.
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spelling pubmed-49382702016-07-11 Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population Barbosa, Ângela Marques Prestes-Carneiro, Luiz Euribel Sobral, Aldri Roberta Sodoschi Sakiyama, Marcelo Jun Lemos, Bruna Cerávolo de Abreu, Marilda Aparecida Milanez Morgado Martos, Luciana Leite Crivelin Moliterno, Ricardo Alberto An Bras Dermatol Investigation BACKGROUND: Alopecia areata (AA) is a common disorder of unknown etiology that affects approximately 0.7% to 3.8% of patients among the general population. Currently, genetic and autoimmune factors are emphasized as etiopathogenic. Studies linking Human Leukocyte Antigens (HLA) to AA have suggested that immunogenetic factors may play a role in the disease's onset/development. OBJECTIVES: To investigate an association between AA and HLA class I/II in white Brazilians. Methods: Patients and control groups comprised 33 and 112 individuals, respectively. DNA extraction was performed by column method with BioPur kit. Allele's classification was undertaken using the PCR-SSO technique. HLA frequencies were obtained through direct counting and subjected to comparison by means of the chi-square test. RESULTS: Most patients were aged over 16, with no familial history, and developed partial AA, with no recurrent episodes. Patients showed a higher frequency of HLA-B*40, HLA-B*45, HLA-B*53 and HLA-C*04 compared with controls, although P was not significant after Bonferroni correction. Regarding HLA class II, only HLA-DRB1*07 revealed statistical significance; nevertheless, it featured more prominently in controls than patients (P=0.04; Pc=0.52; OR=0.29; 95%; CI=0.07 to 1.25). P was not significant after Bonferroni correction. CONCLUSIONS: The development of AA does not seem to be associated with HLA in white Brazilians, nor with susceptibility or resistance. The studies were carried out in populations with little or no miscegenation, unlike the Brazilian population in general, which could explain the inconsistency found. Sociedade Brasileira de Dermatologia 2016 /pmc/articles/PMC4938270/ /pubmed/27438193 http://dx.doi.org/10.1590/abd1806-4841.20164250 Text en © 2016 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License which permits unrestricted non-commercial use, distribution, and reproduction in any medium provided the original work is properly cited.
spellingShingle Investigation
Barbosa, Ângela Marques
Prestes-Carneiro, Luiz Euribel
Sobral, Aldri Roberta Sodoschi
Sakiyama, Marcelo Jun
Lemos, Bruna Cerávolo
de Abreu, Marilda Aparecida Milanez Morgado
Martos, Luciana Leite Crivelin
Moliterno, Ricardo Alberto
Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population
title Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population
title_full Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population
title_fullStr Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population
title_full_unstemmed Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population
title_short Lack of association between alopecia areata and HLA class I and II in a southeastern Brazilian population
title_sort lack of association between alopecia areata and hla class i and ii in a southeastern brazilian population
topic Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938270/
https://www.ncbi.nlm.nih.gov/pubmed/27438193
http://dx.doi.org/10.1590/abd1806-4841.20164250
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