DC vaccine generated by ALA-PDT-induced immunogenic apoptotic cells for skin squamous cell carcinoma

Dendritic cell (DC) vaccines were generated by apoptotic squamous cell carcinoma (SCC) cells induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). ALA-PDT-DC vaccine inhibited the growth of SCC in mice, indicating that immunogenic apoptotic cells can activate an effective antit...

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Detalles Bibliográficos
Autores principales: Ji, Jie, Zhang, Yunfeng, Chen, Wei R., Wang, Xiuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938317/
https://www.ncbi.nlm.nih.gov/pubmed/27471605
http://dx.doi.org/10.1080/2162402X.2015.1072674
Descripción
Sumario:Dendritic cell (DC) vaccines were generated by apoptotic squamous cell carcinoma (SCC) cells induced by 5-aminolevulinic acid (ALA)-mediated photodynamic therapy (PDT). ALA-PDT-DC vaccine inhibited the growth of SCC in mice, indicating that immunogenic apoptotic cells can activate an effective antitumor adaptive immunity and lead to a DC vaccine-based cancer immunotherapy.

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