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Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival
Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938379/ https://www.ncbi.nlm.nih.gov/pubmed/27471625 http://dx.doi.org/10.1080/2162402X.2016.1154250 |
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author | Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Karagiannis, Sophia N. Ahlstedt, Staffan Malmstrom, Håkan Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Ng, Tony Van Hemelrijck, Mieke |
author_facet | Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Karagiannis, Sophia N. Ahlstedt, Staffan Malmstrom, Håkan Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Ng, Tony Van Hemelrijck, Mieke |
author_sort | Wulaningsih, Wahyu |
collection | PubMed |
description | Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE ≥35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan–Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70–0.99. A similar trend was seen with specific IgE scores overall (P(trend) = 0.007) and in women (P(trend) = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (T(H)2)-biased response in development of some cancers. |
format | Online Article Text |
id | pubmed-4938379 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-49383792016-07-28 Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Karagiannis, Sophia N. Ahlstedt, Staffan Malmstrom, Håkan Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Ng, Tony Van Hemelrijck, Mieke Oncoimmunology Original Research Prior findings linking allergy and cancer have been inconsistent, which may be driven by diverse assessment methods. We used serum specific immunoglobulin E (IgE) against common inhalant allergens that was assessed prior to cancer diagnosis in studying this association. We selected 8,727 Swedish men and women who had measurements of serum allergen-specific IgE and total IgE between 1992 and 1996. Multivariable Cox regression using age as a timescale was performed to assess the associations of IgE sensitization, defined by any levels of serum specific IgE ≥35 kU/L, with risk of overall and specific cancers. A test for trend was performed by assigning scores derived from allergen-specific IgE levels at baseline as an ordinal scale. Kaplan–Meier curves and log-rank test were used to assess cancer survival by IgE sensitization status. During a mean follow-up of 16 year, 689 persons were diagnosed with cancer. We found an inverse association between IgE sensitization and cancer risk, with a hazard ratio (HR) of 0.83 and 95% confidence intervals (CI) of 0.70–0.99. A similar trend was seen with specific IgE scores overall (P(trend) = 0.007) and in women (P(trend) = 0.01). Although IgE sensitization was not associated with risk of common site-specific cancers, serum specific IgE scores were inversely associated with melanoma risk in men and women combined, and with risk of female breast and gynecological cancers combined. No association with survival was observed. The association between circulating IgE levels and incident cancer may point toward a role of T-helper 2 (T(H)2)-biased response in development of some cancers. Taylor & Francis 2016-03-28 /pmc/articles/PMC4938379/ /pubmed/27471625 http://dx.doi.org/10.1080/2162402X.2016.1154250 Text en © 2016 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Original Research Wulaningsih, Wahyu Holmberg, Lars Garmo, Hans Karagiannis, Sophia N. Ahlstedt, Staffan Malmstrom, Håkan Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Ng, Tony Van Hemelrijck, Mieke Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival |
title | Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival |
title_full | Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival |
title_fullStr | Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival |
title_full_unstemmed | Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival |
title_short | Investigating the association between allergen-specific immunoglobulin E, cancer risk and survival |
title_sort | investigating the association between allergen-specific immunoglobulin e, cancer risk and survival |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938379/ https://www.ncbi.nlm.nih.gov/pubmed/27471625 http://dx.doi.org/10.1080/2162402X.2016.1154250 |
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