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Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis

OBJECTIVE: The prevalence of type 2 diabetes is increasing rapidly in the young population. The clinical characteristics and risk factors for young type 2 diabetes patients with atherosclerosis are not fully explicated. The aim of the present study was to investigate various clinical and biochemical...

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Autores principales: Yang, Wenjia, Cai, Xiaoling, Han, Xueyao, Ji, Linong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938383/
https://www.ncbi.nlm.nih.gov/pubmed/27391819
http://dx.doi.org/10.1371/journal.pone.0159055
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author Yang, Wenjia
Cai, Xiaoling
Han, Xueyao
Ji, Linong
author_facet Yang, Wenjia
Cai, Xiaoling
Han, Xueyao
Ji, Linong
author_sort Yang, Wenjia
collection PubMed
description OBJECTIVE: The prevalence of type 2 diabetes is increasing rapidly in the young population. The clinical characteristics and risk factors for young type 2 diabetes patients with atherosclerosis are not fully explicated. The aim of the present study was to investigate various clinical and biochemical characteristics of young type 2 diabetic patients with atherosclerosis. DESIGN AND METHODS: This was a cross-sectional study. The study involved 2199 hospitalized patients with type 2 diabetes. The young patients were classified into the atherosclerotic group or the non-atherosclerotic group, and we also enrolled an older group with peripheral atherosclerosis disease and an age of at least 45 years. Comparisons were made between the different groups to investigate the cardiovascular and metabolic risk profiles of young type 2 diabetes patients with atherosclerosis. We also used logistic regression models to assess the atherosclerosis risk factors for young patients. RESULTS: Compared to older type 2 diabetes patients with atherosclerosis, young patients with atherosclerosis had more deleterious profiles of weight and hyperlipidemia. Only age and diabetes duration were found to be significant independent risk factors for atherosclerosis in young patients. The ratio of the presence of atherosclerosis in the lower extremity arteries alone was significantly higher in young patients than older patients (26.4% vs. 14.0%, P = 0.000). CONCLUSION: Young type 2 diabetes patients with atherosclerosis have more adverse cardiovascular risk profiles and inadequate control of these risk factors. Lower extremity examination is of high importance in young patients.
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spelling pubmed-49383832016-07-22 Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis Yang, Wenjia Cai, Xiaoling Han, Xueyao Ji, Linong PLoS One Research Article OBJECTIVE: The prevalence of type 2 diabetes is increasing rapidly in the young population. The clinical characteristics and risk factors for young type 2 diabetes patients with atherosclerosis are not fully explicated. The aim of the present study was to investigate various clinical and biochemical characteristics of young type 2 diabetic patients with atherosclerosis. DESIGN AND METHODS: This was a cross-sectional study. The study involved 2199 hospitalized patients with type 2 diabetes. The young patients were classified into the atherosclerotic group or the non-atherosclerotic group, and we also enrolled an older group with peripheral atherosclerosis disease and an age of at least 45 years. Comparisons were made between the different groups to investigate the cardiovascular and metabolic risk profiles of young type 2 diabetes patients with atherosclerosis. We also used logistic regression models to assess the atherosclerosis risk factors for young patients. RESULTS: Compared to older type 2 diabetes patients with atherosclerosis, young patients with atherosclerosis had more deleterious profiles of weight and hyperlipidemia. Only age and diabetes duration were found to be significant independent risk factors for atherosclerosis in young patients. The ratio of the presence of atherosclerosis in the lower extremity arteries alone was significantly higher in young patients than older patients (26.4% vs. 14.0%, P = 0.000). CONCLUSION: Young type 2 diabetes patients with atherosclerosis have more adverse cardiovascular risk profiles and inadequate control of these risk factors. Lower extremity examination is of high importance in young patients. Public Library of Science 2016-07-08 /pmc/articles/PMC4938383/ /pubmed/27391819 http://dx.doi.org/10.1371/journal.pone.0159055 Text en © 2016 Yang et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Yang, Wenjia
Cai, Xiaoling
Han, Xueyao
Ji, Linong
Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
title Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
title_full Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
title_fullStr Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
title_full_unstemmed Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
title_short Clinical Characteristics of Young Type 2 Diabetes Patients with Atherosclerosis
title_sort clinical characteristics of young type 2 diabetes patients with atherosclerosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938383/
https://www.ncbi.nlm.nih.gov/pubmed/27391819
http://dx.doi.org/10.1371/journal.pone.0159055
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