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Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort
OBJECTIVE: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. METHODS: In the Malmö Diet and Cancer coh...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938491/ https://www.ncbi.nlm.nih.gov/pubmed/27391324 http://dx.doi.org/10.1371/journal.pone.0158959 |
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author | Dias, Joana A. Fredrikson, Gunilla N. Ericson, Ulrika Gullberg, Bo Hedblad, Bo Engström, Gunnar Borgquist, Signe Nilsson, Jan Wirfält, Elisabet |
author_facet | Dias, Joana A. Fredrikson, Gunilla N. Ericson, Ulrika Gullberg, Bo Hedblad, Bo Engström, Gunnar Borgquist, Signe Nilsson, Jan Wirfält, Elisabet |
author_sort | Dias, Joana A. |
collection | PubMed |
description | OBJECTIVE: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. METHODS: In the Malmö Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55–73 years at baseline (1991–96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31(st), 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression. RESULTS: Inverse associations with breast cancer were seen in fully-adjusted models, for 2(nd) and 3(rd) tertiles of ox-LDL, OR (95% CI): 0.65 (0.47–0.90), 0.63 (0.45–0.89) respectively, p-trend = 0.01; and for the 3(rd) tertile of TNF-α, 0.65 (0.43–0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05–2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer. CONCLUSION: Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer. |
format | Online Article Text |
id | pubmed-4938491 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-49384912016-07-22 Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort Dias, Joana A. Fredrikson, Gunilla N. Ericson, Ulrika Gullberg, Bo Hedblad, Bo Engström, Gunnar Borgquist, Signe Nilsson, Jan Wirfält, Elisabet PLoS One Research Article OBJECTIVE: Although cancer promotes inflammation, the role of inflammation in tumor-genesis is less well established. The aim was to examine if low-grade inflammation is related to post-menopausal breast cancer risk, and if obesity modifies this association. METHODS: In the Malmö Diet and Cancer cohort, a nested case-control study was defined among 8,513 women free of cancer and aged 55–73 years at baseline (1991–96); 459 were diagnosed with invasive breast cancer during follow-up (until December 31(st), 2010). In laboratory analyses of blood from 446 cases, and 885 controls (matched on age and date of blood sampling) we examined systemic inflammation markers: oxidized (ox)-LDL, interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, white blood cells, lymphocytes and neutrophils. Odds ratios (OR) and 95% confidence intervals (CI) for breast cancer risk was calculated using multivariable conditional logistic regression. RESULTS: Inverse associations with breast cancer were seen in fully-adjusted models, for 2(nd) and 3(rd) tertiles of ox-LDL, OR (95% CI): 0.65 (0.47–0.90), 0.63 (0.45–0.89) respectively, p-trend = 0.01; and for the 3(rd) tertile of TNF-α, 0.65 (0.43–0.99), p-trend = 0.04. In contrast, those in the highest IL-1β category had higher risk, 1.71 (1.05–2.79), p-trend = 0.01. Obesity did not modify associations between inflammation biomarkers and breast cancer. CONCLUSION: Our study does not suggest that low-grade inflammation increase the risk of post-menopausal breast cancer. Public Library of Science 2016-07-08 /pmc/articles/PMC4938491/ /pubmed/27391324 http://dx.doi.org/10.1371/journal.pone.0158959 Text en © 2016 Dias et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Dias, Joana A. Fredrikson, Gunilla N. Ericson, Ulrika Gullberg, Bo Hedblad, Bo Engström, Gunnar Borgquist, Signe Nilsson, Jan Wirfält, Elisabet Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort |
title | Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort |
title_full | Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort |
title_fullStr | Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort |
title_full_unstemmed | Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort |
title_short | Low-Grade Inflammation, Oxidative Stress and Risk of Invasive Post-Menopausal Breast Cancer - A Nested Case-Control Study from the Malmö Diet and Cancer Cohort |
title_sort | low-grade inflammation, oxidative stress and risk of invasive post-menopausal breast cancer - a nested case-control study from the malmö diet and cancer cohort |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938491/ https://www.ncbi.nlm.nih.gov/pubmed/27391324 http://dx.doi.org/10.1371/journal.pone.0158959 |
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