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Autophagy and Mitochondrial Dysfunction in Tenon Fibroblasts from Exfoliation Glaucoma Patients

PURPOSE: To test the hypothesis that autophagy dysfunction is involved in exfoliation syndrome (XFS), a systemic disorder of extracellular elastic matrices that causes a distinct form of human glaucoma. METHODS: Fibroblasts derived from tenon tissue discards (TFs) from filtration surgery to relieve...

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Detalles Bibliográficos
Autores principales: Want, Andrew, Gillespie, Stephanie R., Wang, Zheng, Gordon, Ronald, Iomini, Carlo, Ritch, Robert, Wolosin, J. Mario, Bernstein, Audrey M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938507/
https://www.ncbi.nlm.nih.gov/pubmed/27391778
http://dx.doi.org/10.1371/journal.pone.0157404