CRISPR/Cas9-Mediated Insertion of loxP Sites in the Mouse Dock7 Gene Provides an Effective Alternative to Use of Targeted Embryonic Stem Cells

Targeted gene mutation in the mouse is a primary strategy to understand gene function and relation to phenotype. The Knockout Mouse Project (KOMP) had an initial goal to develop a public resource of mouse embryonic stem (ES) cell clones that carry null mutations in all genes. Indeed, many useful nov...

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Detalles Bibliográficos
Autores principales: Bishop, Kathleen A., Harrington, Anne, Kouranova, Evguenia, Weinstein, Edward J., Rosen, Clifford J., Cui, Xiaoxia, Liaw, Lucy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2016
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938658/
https://www.ncbi.nlm.nih.gov/pubmed/27175020
http://dx.doi.org/10.1534/g3.116.030601

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