Combination inhibition of PI3K and mTORC1 yields durable remissions in orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases

Brain metastases represent the greatest clinical challenge in treating HER2-positive breast cancer. We report the development of orthotopic patient-derived xenografts (PDXs) of HER2-expressing breast cancer brain metastases (BCBM), and their use for the identification of targeted combination therapi...

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Detalles Bibliográficos
Autores principales: Ni, Jing, Ramkissoon, Shakti H., Xie, Shaozhen, Goel, Shom, Stover, Daniel G., Guo, Hanbing, Luu, Victor, Marco, Eugenio, Ramkissoon, Lori A., Kang, Yun Jee, Hayashi, Marika, Nguyen, Quang-De, Ligon, Azra H., Du, Rose, Claus, Elizabeth B., Alexander, Brian M., Yuan, Guo-Cheng, Wang, Zhigang C., Iglehart, J. Dirk, Krop, Ian E., Roberts, Thomas M., Winer, Eric P., Lin, Nancy U., Ligon, Keith L., Zhao, Jean J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938731/
https://www.ncbi.nlm.nih.gov/pubmed/27270588
http://dx.doi.org/10.1038/nm.4120

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