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Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis

Many epidemiological studies have found that tooth loss is associated with susceptibility to oesophageal cancer. However, a definitive answer is yet to be discovered, and the findings are inconclusive. We performed a meta-analysis to assess the relationship between tooth loss and oesophageal cancer...

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Autores principales: Wang, Yadong, Peng, Juxiang, Li, Yan, Luo, Hong, Huang, Guanglei, Luo, Siyang, Yin, Xinhai, Song, Jukun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938834/
https://www.ncbi.nlm.nih.gov/pubmed/27441139
http://dx.doi.org/10.1186/s40064-016-2711-6
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author Wang, Yadong
Peng, Juxiang
Li, Yan
Luo, Hong
Huang, Guanglei
Luo, Siyang
Yin, Xinhai
Song, Jukun
author_facet Wang, Yadong
Peng, Juxiang
Li, Yan
Luo, Hong
Huang, Guanglei
Luo, Siyang
Yin, Xinhai
Song, Jukun
author_sort Wang, Yadong
collection PubMed
description Many epidemiological studies have found that tooth loss is associated with susceptibility to oesophageal cancer. However, a definitive answer is yet to be discovered, and the findings are inconclusive. We performed a meta-analysis to assess the relationship between tooth loss and oesophageal cancer risk. We searched PubMed and Embase databases to screen eligible studies up to June 2015. Nine observational studies (eight articles) involving 2604 patients and 113,995 participants were included in the meta-analysis. The combined odds ratio for tooth loss and oesophageal cancer was 1.53 (95 % CI 1.02–2.29) for the high versus lowest teeth loss categories. However, inconsistent results were detected in the stratified and sensitivity analysis. In dose–response analysis, the summary odds ratio for each one tooth loss increment was 1.01 (95 % CI 1.00–1.02). The current evidence, based solely on six case–control studies and three cohort studies, suggests that tooth loss is a potential marker of oesophageal cancer. However, no firm conclusion can be drawn at this time that tooth loss may play a causal role in development of oesophageal cancer. Additional large-scale and high-quality prospective studies are required to evaluate the association between tooth loss and risk of oesophageal cancer.
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spelling pubmed-49388342016-07-20 Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis Wang, Yadong Peng, Juxiang Li, Yan Luo, Hong Huang, Guanglei Luo, Siyang Yin, Xinhai Song, Jukun Springerplus Research Many epidemiological studies have found that tooth loss is associated with susceptibility to oesophageal cancer. However, a definitive answer is yet to be discovered, and the findings are inconclusive. We performed a meta-analysis to assess the relationship between tooth loss and oesophageal cancer risk. We searched PubMed and Embase databases to screen eligible studies up to June 2015. Nine observational studies (eight articles) involving 2604 patients and 113,995 participants were included in the meta-analysis. The combined odds ratio for tooth loss and oesophageal cancer was 1.53 (95 % CI 1.02–2.29) for the high versus lowest teeth loss categories. However, inconsistent results were detected in the stratified and sensitivity analysis. In dose–response analysis, the summary odds ratio for each one tooth loss increment was 1.01 (95 % CI 1.00–1.02). The current evidence, based solely on six case–control studies and three cohort studies, suggests that tooth loss is a potential marker of oesophageal cancer. However, no firm conclusion can be drawn at this time that tooth loss may play a causal role in development of oesophageal cancer. Additional large-scale and high-quality prospective studies are required to evaluate the association between tooth loss and risk of oesophageal cancer. Springer International Publishing 2016-07-08 /pmc/articles/PMC4938834/ /pubmed/27441139 http://dx.doi.org/10.1186/s40064-016-2711-6 Text en © The Author(s) 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research
Wang, Yadong
Peng, Juxiang
Li, Yan
Luo, Hong
Huang, Guanglei
Luo, Siyang
Yin, Xinhai
Song, Jukun
Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
title Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
title_full Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
title_fullStr Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
title_full_unstemmed Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
title_short Association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
title_sort association between tooth loss and risk of oesophageal cancer: a dose–response meta-analysis
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4938834/
https://www.ncbi.nlm.nih.gov/pubmed/27441139
http://dx.doi.org/10.1186/s40064-016-2711-6
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