In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity

BACKGROUND: Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) loss of function is frequently detected in advanced colorectal cancer. Its detection is thought to have prognostic significance and it is being considered to predict responsiveness to anti-EGFR therapy. Unfortunately, while i...

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Detalles Bibliográficos
Autores principales: Ágoston, Emese Irma, Micsik, Tamás, Ács, Balázs, Fekete, Krisztina, Hahn, Oszkár, Baranyai, Zsolt, Dede, Kristóf, Bodoky, György, Bursics, Attila, Kulka, Janina, Krenács, Tibor, Győrffy, Balázs, Harsányi, László, Szász, A. Marcell
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939017/
https://www.ncbi.nlm.nih.gov/pubmed/27392434
http://dx.doi.org/10.1186/s13000-016-0508-0

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