Febuxostat, a novel xanthine oxidoreductase inhibitor, improves hypertension and endothelial dysfunction in spontaneously hypertensive rats

Xanthine oxidase (XO) is an enzyme responsible for the production of uric acid. XO produces considerable amount of oxidative stress throughout the body. To date, however, its pathophysiologic role in hypertension and endothelial dysfunction still remains controversial. To explore the possible involv...

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Detalles Bibliográficos
Autores principales: Shirakura, Takashi, Nomura, Johji, Matsui, Chieko, Kobayashi, Tsunefumi, Tamura, Mizuho, Masuzaki, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939152/
https://www.ncbi.nlm.nih.gov/pubmed/27198514
http://dx.doi.org/10.1007/s00210-016-1239-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4939152/
https://www.ncbi.nlm.nih.gov/pubmed/27198514
http://dx.doi.org/10.1007/s00210-016-1239-1

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